蒲公英化学成分和药理作用研究进展及其质量标志物预测分析

Research Progress of Chemical Composition and Pharmacological Effects of Pugongying(Taraxaci Herba)and Its Quality Marker Prediction Analysis

蒲公英Taraxaci Herba是我国药食同源中药材之一。蒲公英化学成分类型丰富,药理作用应用广泛,现代研究表明,蒲公英中富含黄酮类、酚酸类、萜类、糖类、甾醇类、脂肪酸类、色素类等多种化学成分,具有抗肿瘤、抗炎、保肝利胆、抑菌、抗氧化、调节免疫等多重作用功效。通过文献汇总,对蒲公英化学成分和药理作用最新研究进展进行整理总结,并运用质量标志物(quality marker,Q-Marker)核心理念,围绕植物亲缘学及化学成分特有性,成分与药性和药效的关系以及化学成分可测性四个角度,并结合分子对接模拟分析方法,对蒲公英质量标志物预测分析。归纳出咖啡酸、绿原酸、芦丁、槲皮素、蒲公英甾醇、蒲公英多糖等成分可作为蒲公英主要的质量标志物的候选成分,为完善蒲公英质量标准提供依据,以期为蒲公英科学合理的质量控制以及后续的深入研究利用提供参考。

Pugongying(Taraxaci Herba)is one of the Chinese herbs with the homology of medicine and food in China.Pugongying(Taraxaci Herba)a variety of chemical components and a wide range of pharmacological applications.Modern re-search has shown that it is rich in various chemical components such as flavonoids,phenolic acids,terpenoids,sugars,sterols,fatty acids,pigments,etc.It has multiple effects such as anti-tumor,anti-inflammatory,liver and gallbladder protection,anti-bac-teria,antioxidant and immune regulation.This article summarized the latest research progress on the chemical components and pharmacological effects of Pugongying(Taraxaci Herba)through literature review,and applied the core concept of quality markers to predict and analyze the quality markers of Pugongying(Taraxaci Herba)from four perspectives:plant phylogeny and chemical component specificity,the relationship between components and drug properties and efficacy,and the testability of chemical com-ponents.Combined with molecular docking simulation analysis methods,this article predicted and analyzed the quality markers of Pugongying(Taraxaci Herba).Constituents such as caffeic acid,chlorogenic acid,rutin,quercetin,Pugongying(Taraxaci Herba)sterol,and Pugongying(Taraxaci Herba)polysaccharide can be summarized ascandidate components for the main quality indica-tors of Pugongying(Taraxaci Herba),providing a basis for improving the quality standards of Pugongying(Taraxaci Herba)and reference for scientific and reasonable quality control and subsequent in-depth research and utilization of Pugongying(Taraxaci Herba).