小鼠抑郁症模型的构建与评估

Construction and Evaluation of Mouse Depression Models

抑郁症因逐年升高的发病率已经受到了医学界的广泛关注。抑郁症发病因素极其复杂,因此在进行相关实验时构建相应抑郁症模型成为实验关键步骤。本文主要介绍常见小鼠抑郁症模型的构建方法,例如慢性不可预见性温和刺激模型,特殊药物所致抑郁模型,生命早期应激模型等,以及相关评估抑郁程度的行为学实验,例如强迫游泳实验、蔗糖偏好实验、喷溅实验等,为相关研究人员提供实验思路及方法。

Depression has received widespread attention from the medical community due to its increasing incidence year by year.The factors of depression are extremely complex,so the construction of depression models has become a key step when conducting related experiments.This paper mainly introduces the construction method of common mouse depression models,such as chronic unpredictable mild stimulus model,special drug-induced depression model,early life stress model,etc.,and related behavioural experiments to assess the degree of depression,such as forced swimming experiment,sucrose preference experiment,splashing experiment,etc.,which provide relevant researchers with experimental ideas and method.