NFIX基因功能及相关疾病研究进展

Advances in NFIX gene function and related diseases

核因子I(nuclear factor I,NFI)家族是机体重要的转录因子,包含NFIA、NFIB、NFIC和NFIX四个成员,NFI家族成员的N端DNA结合和二聚化结构域高度保守。NFIX基因在大脑、前列腺、骨骼肌、皮肤、脂肪、卵巢等部位广泛表达。NFIX基因在神经系统发育、肿瘤发生、肌肉和骨骼发育、造血细胞增殖及精子发生等多种生物过程中发挥至关重要的作用。目前国内对NFIX基因的功能研究及临床病例报道均较少,其具体作用机制仍未完全明确,有待进一步研究。为引起临床医师对NFIX基因的重视,提高对该基因相关疾病的认识,该文总结近年国内外相关文献,对NFIX基因的功能及临床研究进展进行综述。

The nuclear factor I(NFI)family is a group of important transcription factors,consisting of four members:NFIA,NFIB,NFIC,and NFIX.The members of the NFI family are highly conserved in the N-terminal DNA binding and dimerization domain.The NFIX gene is expressed in many parts of the body,including the brain,prostate,muscles,skin,fat,and ovaries.It plays an important role in a variety of biological processes,including nervous system development,tumorigenesis,muscle and bone development,hematopoietic cell proliferation,and spermatogenesis.Currently,there are few studies and clinical reports on the NFIX gene in China,and its specific mechanism remains unclear,requiring further investigation.To draw the attention of clinicians and enhance the understanding of NFIX gene associated diseases,this article summarizes recent literature and reviews the function and clinical progress of the gene.