阿托伐他汀联合螺内酯治疗慢性心力衰竭伴房颤的临床分析

Atorvastatin Combined with Spironolactone in Treatment of Chronic Heart Failure Clinical Analysis of Atrial Fibrillation

目的观察阿托伐他汀联合螺内酯治疗慢性心力衰竭伴房颤的疗效。方法随机抽取近两年来我中心就诊的90例慢性心力衰竭伴房颤患者作为研究对象,分为观察组和对照组,每组45例。观察组采用阿托伐他汀联合螺内酯治疗,对照组采用螺内酯治疗,比较两组临床疗效、治疗前后心功能指标[左心射血分数(LVEF)、左心舒张收缩末期内径(LVEDD)]、血清生化指标[C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]、不良反应发生情况。结果观察组的治疗效果明显高于对照组。结论阿托伐他汀联合螺内酯治疗慢性心力衰竭并房颤疗效确切,能够有效改善心功能,减轻机体炎症,预后良好,且未增加明显不良反应。

Objective To investigate the efficacy of atorvastatin combined with spironolactone in the treatment of chronic heart failure with atrial fibrillation.Methods A total of 90 patients with chronic heart failure and atrial fibrillation who were treated in our center in the past 2 years were randomly selected as the research objects and divided into two groups:observation group and control group,45 cases in each group.Observation group received atorvastatin combined spironolactone treatment,control group received spironolactone treatment.The clinical efficacy,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD,LVESD)],serum biochemical indexes C-reactive protein(CRP),interleukin 6(IL-6),tumor necrosis factorα(TNF-α)and adverse reactions were compared between the two groups before and after treatment.Results The therapeutic effect of observation group was significantly higher than that of control group.Conclusion Atorvastatin combined with spironolactone is effective in the treatment of patients with chronic heart failure and atrial fibrillation,which can effectively improve heart function,reduce body inflammation,and have a good prognosis without increasing obvious adverse reactions.