行维持性血液透析的尿毒症患者皮肤瘙痒的临床分析

Analysis of clinical characteristics of pruritus in uremia patients undergoing maintenance hemodialysis

目的分析行维持性血液透析的尿毒症患者皮肤瘙痒的临床特征。方法收集行维持性血液透析3个月以上的213例尿毒症患者的临床资料,根据有无皮肤瘙痒将患者分为瘙痒组(111例)和无瘙痒组(102例),比较两组患者临床资料,分析行维持性血液透析的尿毒症患者皮肤瘙痒发生的危险因素。结果与无瘙痒组相比,瘙痒组24-h尿量较少,铁蛋白、甲状旁腺激素水平较高(P<0.05)。多因素logistic回归分析发现,24-h尿量增加是行维持性血液透析的尿毒症患者发生皮肤瘙痒的独立保护性因素(P<0.05)。结论行维持性血液透析的尿毒症患者易出现皮肤瘙痒,24-h尿量与皮肤瘙痒密切相关。

Objective To analyze the clinical characteristics of pruritus in the uremia patients undergoing maintenance hemodialysis.Methods The clinical data of 213 uremia patients undergoing maintenance hemodialysis for more than 3 months were collected,who were divided into two groups of A(with pruritus,111 cases)and B(without pruritus,102 cases).The relevant data were analyzed between the two groups.The risk factors of pruritus in maintenance hemodialysis patients were analyzed.Results Compared with group B,the 24-hour urine volume was lower,and the levels of ferritin and parathyroid hormone were higher in group A(P<0.05).Multivariate logistic regression analysis showed that increased 24-hour urine volume was the independent protective factor for pruritus(P<0.05).Conclusion Pruritus is prone to occurring in the uremia patients undergoing maintenance hemodialysis.Increased 24-hour urine volume is closely related to pruritus.