健康体检人群非酒精性脂肪性肝病患病状况及危险因素分析

Analysis of prevalence and risk factors for non-alcoholic fatty liver disease in health examination population

目的分析健康体检人群非酒精性脂肪性肝病(NAFLD)的患病状况及相关危险因素。方法收集健康体检人群22816例的相关资料,采用多因素logistic回归分析NAFLD发生的危险因素。结果22816例体检者中,10557例患有NAFLD,不同年龄和BMI的体检者NAFLD患病率有统计学差异(P<0.05)。男性、高血压、FBG增高、血脂异常、肝功能异常、血尿酸(SUA)增高、幽门螺杆菌阳性的体检者NAFLD患病率较高(P<0.05)。正常、超重、肥胖组男性NAFLD患病率高于女性(P<0.05)。男性、超重、肥胖、高血压、FBG增高、血脂异常、肝功能异常、SUA增高是健康体检人群发生NAFLD的独立危险因素(P<0.05),偏瘦是独立保护因素(P<0.05)。结论健康体检人群有较高的NAFLD患病率,男性、超重、肥胖、高血压、FBG增高、血脂异常、肝功能异常和SUA增高是健康体检人群发生NAFLD的危险因素。

Objective To analyze the prevalence and risk factors for non-alcoholic fatty liver disease(NAFLD)in health examination population.Methods The data of 22816 people underwent health examination were collected.Multivariate logistic regression was used to analyze the risk factors for NAFLD.Results Of 22816 health examination people,10557 cases had NAFLD,which had significant differences in the prevalence of NAFLD among patients with different age and BMI(P<0.05).The prevalence of NAFLD was higher in males and people with hypertension,increased FBG,dyslipidemia,abnormal liver function,increased serum uric acid(SUA)and Hp positive(P<0.05).The prevalence of NAFLD in normal,overweight and obese men was higher than that in women(P<0.05).Male,overweight,obesity,hypertension,increased FBG,dyslipidemia,abnormal liver function,and increased SUA were the independent risk factors for NAFLD in health examination population,and underweight was an independent protective factor for NAFLD(P<0.05).ConclusionThe prevalence of NAFLD in health examination population is higher.Male,overweight,obesity,hypertension,increased FBG,dyslipidemia,abnormal liver function,and increased SUA are the risk factors for NAFLD.