粒子特性对纳米粒子跨膜输运过程的影响

Effect of Particle Properties on the Transmembrane Transport Process of Nanoparticles

纳米粒子由于其特异性强、选择性高等特点被广泛用作药物载体,研究纳米粒子与生物膜相互作用机制具有重要的理论和实际意义.文章采用自洽场理论研究了纳米粒子跨膜运输的过程,系统探讨了纳米粒子特性对粒子跨膜输运过程的影响.结果表明,纳米粒子穿膜过程中,通过挤压双层膜形成特定通道,从而促使粒子进入囊泡.通过计算不同特性纳米粒子进入囊泡过程中体系的自由能、熵、焓的变化情况,进一步分析了粒子跨膜运输的物理机制,并找到了纳米粒子穿膜的最佳形状,为进一步理解纳米粒子与生物膜相互作用机制提供了参考.

As a wide range of drug carriers,nanoparticles can effectively protect the medicinal properties of carrying drugs through the biofilms and increase the slow release time.Compared with traditional drugs,vesicles re-present the biofilm phospholipid bilayer structure,and drugs relying on nanoparticles into the cell membrane have lower damage and better targeting to the cell membrane.We study the process of nanoparticle cross-membrane transport using self-consistent mean-field theory.In the initial state,the nanoparticles have some distance from the vesicle,and as the distance between the nanoparticles and the vesicles decreases,it is shown that the nanoparticles will form specific channels by squeezing the vesicle,thus prompting the particles into the vesicle.This paper discus-ses the changes of free energy,entropy and enthalpy in the process of entering nanoparticles of different shapes.Through the analysis of free energy,entropy and enthalpy change curves,the most appropriate shape of nanoparticles is selected as rod nanoparticles,and finds the best shape of nanoparticles through the membrane.Our results provide good guidance for the experimental design of nanodrug carriers.