四君子汤加减辅助治疗慢性胃炎患者的效果

The Effect of Modified Sijunzi Decoction as an Adjunctive Treatment for Patients with Chronic Gastritis

目的:探讨四君子汤加减辅助治疗慢性胃炎患者的效果。方法:选取2019年5月—2023年4月泰宁县中医院收治的86例慢性胃炎患者作为研究对象,以随机数表法分为常规组和中药组,每组各43例。常规组采用四联疗法治疗,中药组在其基础上加以四君子汤加减治疗。比较两组临床疗效、胃黏膜分泌功能、肠道菌群结构以及不良反应情况。结果:中药组治疗有效率高于常规组,差异有统计学意义(P<0.05);中药组胃泌素(GAS)、一氧化氮(NO)、胃黏膜前列腺素2(PGE2)水平均高于常规组,差异有统计学意义(P<0.05);中药组各菌门含量均高于常规组,差异有统计学意义(P<0.05);中药组恶心/呕吐发生率较常规组低,差异有统计学意义(P<0.05);其余不良反应对比,差异无统计学意义(P>0.05)。结论:在慢性胃炎患者中加以四君子汤加减辅助治疗疗效显著,能够增强患者肠道菌群丰度的调节,以促进胃黏膜分泌功能恢复,且不良反应相对较少,用药安全性较高。

Objective:To explore the effect of Sijunzi decoction in the treatment of chronic gastritis.Method:A total of 86 patients with chronic gastritis admitted to Taining County Traditional Chinese Medicine Hospital of Traditional Chinese Medicine from May 2019 to April 2023 were selected and divided into two groups by random number table method,with 43 cases in each group.The conventional group was treated with quadruple therapy,while the traditional Chinese medicine group was treated with Sijunzi decoction on the basis of quadruple therapy.The clinical efficacy,gastric mucosal secretion function,intestinal flora structure and adverse reactions of the two groups were compared.Result:The effective rate of treatment in the traditional Chinese medicine group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).The levels of gastrin(GAS),nitric oxide(NO),and gastric mucosal prostaglandin 2(PGE2)in the traditional Chinese medicine group were higher than those in the conventional group,and the differences were statistically significant(P<0.05).The content of various bacterial phyla in the traditional Chinese medicine group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).The incidence of nausea or vomiting in the traditional Chinese medicine group was lower than that in the conventional group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the comparison of other adverse reactions(P>0.05).Conclusion:Sijunzi decoction is effective in chronic gastritis patients,and it can enhance the regulation of intestinal flora abundance in patients,so as to promote the recovery of gastric mucosal secretion function,with relatively few adverse reactions and high drug safety.