葛根芩连汤合白头翁汤治疗湿热型溃疡性结肠炎的效果

Effectiveness of Gegen Qinlian Decoction Combined with Baitouweng Decoction in the Treatment of Damp-Heat Type Ulcerative Colitis

目的:探讨湿热型溃疡性结肠炎(UC)患者应用葛根芩连汤合白头翁汤治疗的效果。方法:选取2021年3月—2023年3月莆田涵江医院收治的98例UC患者作为研究对象,采用随机数表法分为对照组和观察组,每组各49例。对照组给予西药柳氮磺吡啶治疗,观察组加用葛根芩连汤合白头翁汤治疗,共治疗4周。对比两组治疗效果、不良反应及复发情况。结果:观察组治疗后中医症候积分、疾病活动指数(DAI)评分、Baron内镜评分及炎症因子、CD8^(+)水平低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组,治疗总有效率高于对照组,复发率低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:湿热型UC患者应用葛根芩连汤合白头翁汤治疗可有效减轻炎症反应,改善患者免疫功能,降低复发率,安全有效,利于加快UC康复进程。

Objective:To investigate the effect of applying Gegen Qinlian decoction combined with Baitouweng decoction in the treatment of patients with damp-heat type ulcerative colitis(UC).Method:98 cases of UC patients admitted to Putian Hanjiang Hospital from March 2021 to March 2023 were selected as the study subjects,and were divided into a control group and an observation group using the random number table method,with 49 cases in each group.The patients in the control group were given western medicine salicylazosulfapyridine treatment,and the patients in the observation group were treated with Gegen Qinlian decoction combined with Baitouweng decoction for a total of 4 weeks.The treatment effect,adverse reactions and recurrence of the two groups were compared.Result:Compared to the control group,the patients in the observation group had lower TCM symptom score,disease activity index(DAI)score,Baron endoscopy score and inflammatory factor and CD8^(+)level after treatment,and they had higher CD3^(+),CD4^(+),CD4^(+)/CD8^(+)level than those in the control group.The total effective rate of treatment in the observation group was higher than that in the control group,and the relapse rate was lower than that in the control group,and the difference was statistically significant(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion:The treatment of UC patients with damp-heat type by applying Gegen Qinlian decoction combined with Baitouweng decoction can effectively reduce the inflammatory reaction,improve the immune function of patients,reduce the recurrence rate,which is safe and effective,and is conducive to accelerating the recovery process of UC.