参麦注射液对结直肠癌术后辅助化疗患者免疫功能及疲劳评分的影响

Effect of Shenmai Injection on Immune Function and Fatigue Score in Patients with Postoperative Adjuvant Chemotherapy for Colorectal Cancer

目的:探讨参麦注射液对结直肠癌(CRC)术后辅助化疗患者免疫功能及疲劳评分的影响。方法:选取2021年7月—2023年5月莆田九十五医院行手术治疗的92例CRC患者作为研究对象,按随机数表法分为对照组和治疗组,每组各46例。对照组术后予以辅助化疗,治疗组基于对照组予以参麦注射液治疗。比较两组肿瘤标志物指标、免疫功能指标、疲劳评分、睡眠状况及毒副反应发生情况。结果:治疗后,治疗组糖类抗原724(CA724)、癌胚抗原(CEA)、糖类抗原199(CA199)、CD8^(+)水平较对照组低,CD4^(+)、NK水平较对照组高,差异有统计学意义(P<0.05);治疗后,治疗组Piper疲乏修订量表(PFS-R)评分、匹兹堡睡眠质量指数(PSQI)较对照组低,差异有统计学意义(P<0.05);治疗组相关毒副反应发生率较对照组低,差异无统计学意义(P>0.05)。结论:CRC术后辅助化疗患者采用参麦注射液治疗可降低肿瘤标志物水平,调节免疫功能,改善患者疲劳与睡眠状况,且可在一定程度上减少毒副反应的发生。

Objective:To investigate the effects of Shenmai injection on immune function and fatigue scores in patients with postoperative adjuvant chemotherapy for colorectal cancer(CRC).Method:92 cases of CRC patients who underwent surgical treatment in Pution 95 Hospital from July 2021 to May 2023 were selected as the study subjects,and were divided into a control group and a treatment group according to the method of randomized number table,with 46 cases in each group.Patients in the control group were treated with adjuvant chemotherapy after surgery,and patients in the treatment group were treated with ginseng-mai injection on the basis of the control group.Tumor marker indexes,immune function indexes,fatigue score,sleep status and the occurrence of toxic side effects were compared between the two groups.Result:After treatment,patients in the treatment group had lower levels of glycoconjugate antigen 724(CA724),carcinoembryonic antigen(CEA),glycoconjugate antigen 199(CA199)and CD8^(+),and higher levels of CD4^(+)and NK compared with the control group,and the difference was statistically significant(P<0.05).After treatment,patients in the treatment group had lower Piper Fatigue Revision Scale(PFS-R)scores and Pittsburgh Sleep Quality Index(PSQI)than those in the control group,and the difference was statistically significant(P<0.05).The incidence of related toxic side effects in the treatment group was lower than that in the control group,and the difference was not statistically significant(P<0.05).Conclusion:Patients with adjuvant chemotherapy treated with shenmai injection after CRC,it can reduce tumor marker levels,regulate immune function,improve fatigue and sleep,and also can reduce the occurrence of toxic side effects to a certain extent.