复方倍他米松辅助玻璃酸钠关节腔内注射治疗膝关节滑膜炎的效果

Effect of Compound Betamethasone Assisted Intra-articular Injection of Sodium Hyaluronate in the Treatment of Knee Synovitis

目的:探讨复方倍他米松辅助玻璃酸钠关节腔内注射治疗膝关节滑膜炎(KS)的效果。方法:选取2022年2月—2023年2月莆田九十五医院接收的87例KS患者作为研究对象,根据随机数表法分为对照组(n=44)和研究组(n=43)。对照组予以玻璃酸钠关节腔内注射治疗,研究组予以复方倍他米松辅助治疗,比较两组疗效、滑膜厚度与关节腔内积液量、炎症反应指标及关节功能情况。结果:研究组总有效率(90.70%)高于对照组(70.45%),差异有统计学意义(P<0.05);两组治疗4周后白细胞介素1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)水平、滑膜厚度、关节腔内积液量较治疗前低,Lysholm膝关节功能评分较治疗前高,且研究组上述指标优于对照组,差异有统计学意义(P<0.05)。结论:KS患者采用复方倍他米松辅助玻璃酸钠关节腔内注射治疗效果较好,可减少滑膜厚度与关节腔内积液量,减轻炎症反应,提高关节功能。

Objective:To explore the effect of compound betamethasone assisted intra-articular injection of sodium hyaluronate in the treatment of knee synovitis(KS).Method:According to the random number table method,87 KS patients admitted to Putian 95 Hospital from February 2022 to February 2023 were divided into a control group(n=44)and a study group(n=43).The control group received intra-articular injection of sodium hyaluronate,while the study group received adjuvant treatment with compound betamethasone.The efficacy,synovial thickness,joint cavity fluid accumulation,inflammatory response indicators and joint function were compared between two groups.Result:The total effective rate of the study group was 90.70%,which was higher than 70.45%of the control group,and the difference was statistically significant(P<0.05).After 4 weeks of treatment,the levels of interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),synovial thickness and intra-articular fluid accumulation were lower than before treatment.The Lysholm knee joint function score was higher than before treatment,and the above indicators in the study group were better than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:The treatment of KS patients using compound betamethasone assisted sodium hyaluronate intra-articular injection has a good effect,reducing synovial thickness and joint effusion,alleviating inflammatory reactions,and improving joint function.