纳洛酮联合醒脑静对急诊急性酒精中毒患者的效果

Effects of Naloxone Combined with Xingnaojing on Emergency Patients with Acute Alcoholism

目的:研究在纳洛酮治疗基础上增用醒脑静改善急诊急性酒精中毒(AA)患者的效果。方法:选取2022年1月—2023年10月监利市人民医院收治的91例AA患者作为研究对象。按照随机数表发分为联合组(n=45)及单一用药组(n=46)。单一用药组选用纳洛酮治疗,联合组则于单一用药组的基础上联合醒脑静治疗。比较两组治疗效果、神经递质水平、氧代谢指标水平及不良反应发生情况。结果:联合组苏醒时间、语言恢复时间、行走恢复时间均短于单一用药组,差异有统计学意义(P<0.05)。治疗后,两组各项神经递质水平均低于治疗前,且联合组低于单一用药组,差异有统计学意义(P<0.05)。治疗后两组动脉血氧含量及血氧饱和度水平均高于治疗前,且联合组高于单一用药组,差异有统计学意义(P<0.05)。在不良反应方面比较,两组差异不明显,差异无统计学意义(P>0.05)。结论:在纳洛酮治疗基础上增用醒脑静对急诊AA患者神经递质水平的改善作用显著,且能促进患者康复,改善氧代谢状态,安全可行。

Objective:To study the effect of adding Xingnaojing to naloxone therapy in patients with Acute alcoholism(AA)Method:A total of 91 AA patients admitted to Jianli People's Hospital from January 2022 to October 2023 were selected as the study objects.They were randomly divided into a combination group consisted of 45 cases and a single medication group consisted of 46 cases according to random nomber method.The single drug group was treated with naloxone,and the combined group was treated with Xingnaojing on the basis of the single drug group.The treatment effect,neurotransmitter level,oxygen metabolism index level and adverse reactions were compared between the two groups.Result:The recovery time,speech recovery time and walking recovery time in combination group were shorter than those in single medication group,and the differences were statistically significant(P<0.05).After treatment,the levels of neurotransmitters in the two groups were lower than those before treatment,and the combined group was lower than the single drug group,and the differences were statistically significant(P<0.05).After treatment,the content of arterial blood oxygen and saturation of blood oxygen in 2 groups were higher than those before treatment,and the combined group was higher than the single drug group,and the differences were statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Naloxone combined with Xingnaojing can significantly improve the neurotransmitter level in patients with emergency acute alcoholism,and also can promote the rehabilitation of patients and improve the oxygen metabolism status,which is safe and feasible.