少腹逐瘀汤佐治气滞血瘀型子宫肌瘤临床观察

Clinical Observation of Shaofu Zhuyu Decoction in the Adjuvant Treatment of Uterine Fibroids of Qi - Stagnation and Blood - Stasis Syndrome

目的 探讨少腹逐瘀汤佐治气滞血瘀型子宫肌瘤的临床疗效。方法 选取张家口市中医院2021年10月至2022年11月收治的气滞血瘀型子宫肌瘤患者90例,按治疗方案的不同分为对照组(44例)和观察组(46例)。两组患者均予米非司酮片口服,观察组患者加服少腹逐瘀汤。两组患者均连续治疗1个月。结果 与对照组比较,观察组患者治疗后的中医证候积分显著降低;子宫体积及子宫肌瘤体积显著减小;卵泡刺激素、黄体生成素、雌二醇、孕酮、睾酮水平显著降低;血管内皮生长因子、基质金属蛋白酶-2(MMP-2)水平显著降低,基质金属蛋白酶组织抑制因子-2(TIMP-2)水平显著升高,MMP-2/TIMP-2比值显著降低(P <0.05)。结论 少腹逐瘀汤佐治气滞血瘀型子宫肌瘤,可明显减小患者子宫及子宫肌瘤的体积,调节性激素水平,降低MMP-2/TIMP-2比值,改善卵巢功能。

Objective To investigate the clinical efficacy of Shaofu Zhuyu Decoction in the adjuvant treatment of uterine fibroids of Qi-stagnation and blood-stasis syndrome.Methods Ninety patients with uterine fibroids of Qi-stagnation and blood-stasis syndrome admitted to the Zhangjiakou Hospital of Traditional Chinese Medicine from October 2021 to November 2022 were selected and divided into the control group(44 cases)and the observation group(46 cases)according to different treatment regimens.The patients in the two groups were given oral Mifepristone Tablets,on this basis,the patients in the observation group were given Shaofu Zhuyu Decoction.Both groups received continuous treatment for one month.Results Compared with those in the control group,the traditional Chinese medicine(TCM)syndrome score in the observation group significantly decreased after treatment;the volumes of the uterus and uterine fibroids significantly decreased;the follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),progesterone(P),and testosterone(T)levels significantly decreased;the vascular endothelial growth factor(VEGF)and matrix metalloproteinase-2(MMP-2)levels significantly decreased,the tissue inhibitor of metalloproteinase-2(TIMP-2)level significantly increased,the MMP-2/TIMP-2 significantly decreased(P<0.05).Conclusion The adjuvant treatment of Shaofu Zhuyu Decoction can significantly decrease the volumes of uterus and uterine fibroids,regulate sex hormone levels,decrease the MMP-2/TIMP-2,and improve the ovarian function in patients with uterine fibroids of Qi-stagnation and blood-stasis syndrome.