益肾健骨方加减联合灸法在骨质疏松性骨痛患者中的应用效果

Effect of Modified Yishen Jiangu Recipe(益肾健骨方加减)Combined with Moxibustion on Patients with Osteoporotic Bone Pain

目的探究益肾健骨方加减联合灸法在骨质疏松性骨痛患者中的应用效果。方法将2021年8月—2022年8月于温州市中医院接受治疗的110例骨质疏松性骨痛患者随机分为对照组及观察组。对照组55例予以常规西药治疗,观察组55例予以益肾健骨方加减联合温和灸法治疗。比较两组治疗前后的疼痛因子水平、静息及活动时的疼痛情况及骨代谢指标水平,对比两组的临床疗效及安全性。结果治疗后,两组血清前列腺素E2(prostaglandin E2,PGE2)、P物质(substance P,SP)和5-羟色胺(5-hydroxytryptamine,5-HT)水平均降低,其中观察组各水平低于对照组(P<0.05);治疗7 d后,两组静息及活动时的视觉模拟评分量表(visual analogue scale,VAS)评分均降低,其中观察组静息及活动时的VAS评分均低于对照组(P<0.05);治疗后,两组血清骨型碱性磷酸酶(bone alkaline phosphatase,BALP)、骨钙素(osteocalcin,BGP)水平均升高,Ⅰ型胶原羟基端肽β特殊序列(type I collagen carboxy terminal peptideβspecial sequence,β-CTX)水平均降低,且观察组各水平变化较对照组更显著(P<0.05);观察组的临床疗效优于对照组(P<0.05),两组不良反应发生率比较差异无统计学意义(P>0.05)。结论益肾健骨方加减联合灸法对骨质疏松性骨痛患者应用效果显著,安全性高,能有效改善患者的疼痛因子水平,缓解疼痛,改善骨代谢水平。

Objective To explore the application effect of Modified Yishen Jiangu Recipe(益肾健骨方加减)combined with moxibustion in patients with osteoporotic bone pain.Methods A total of 110 patients with osteoporotic bone pain who were treated in the hospital from August 2021 to August 2022 were randomly divided into control group and observation group.Fifty-five cases in the control group were treated with conventional western medicine,while 55 cases in the observation group were treated with Modified Yishen Jiangu Recipe combined with mild moxibustion.The levels of pain factors,pain at rest and during activities and bone metabolism indexes before and after treatment were compared between the two groups,and the clinical efficacy and safety of the two groups were compared.Results After treatment,the levels of serum prostaglandin E2(PGE2),substance P(SP)and 5-hydroxytryptamine(5-HT)in the two groups decreased,and the levels in the observation group were lower than those in the control group(P<0.05).After 7 days of treatment,the scores of visual analogue scale(VAS)at rest and activity in both groups decreased,and the VAS scores at rest and activity in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of serum bone alkaline phosphatase(BALP)and osteocalcin(BGP)in both groups were increased,and the hydroxy terminal peptide of type I collagen carboxy terminal peptideβspecial sequence(β-CTX)levels were reduced(P<0.05).The clinical efficacy of the observation group was better than that of the control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Yishen Jiangu Formula combined with moxibustion is effective and safe for patients with osteoporotic bone pain.It can effectively improve the levels of pain factors,relieve the pain and improve the bone metabolism.