西帕依固龈液联合牙周治疗对妊娠期牙周炎的效果评价

Evaluation of the effect of Xipayi mouth rinse combined with periodontal therapy on gestational periodontitis

目的评价对妊娠期牙周炎患者予以西帕依固龈液联合牙周治疗的疗效。方法70例妊娠期牙周炎患者,采用抽签方法分为对照组和试验组,每组35例。对照组予以常规牙周治疗,试验组予以西帕依固龈液联合牙周治疗。对比两组的临床疗效、龈沟液炎性因子[内脂素(VF)、前列腺素E2(PGE2)、单核细胞趋化蛋白(MVP-1)、白细胞介素-6(IL-6)]、牙周指标[牙周袋深度(PD)、牙龈出血指数(SBI)、菌斑指数(PLI)、附着丧失(AL)]、微生物指标、不良反应发生情况、生活质量。结果试验组临床总有效率97.14%明显高于对照组的77.14%(P<0.05)。试验组治疗后VF、PGE2、MVP-1、IL-6水平分别为(31.40±7.55)μg/L、(48.80±6.52)ng/L、(81.38±8.18)ng/L、(3.58±0.61)ng/L,明显低于对照组的(40.59±6.52)μg/L、(56.48±9.05)ng/L、(91.06±10.10)ng/L、(4.36±0.68)ng/L(P<0.05)。试验组治疗后SBI、PLI、AL、PD分为(1.17±0.38)分、(1.11±0.32)分、(2.06±0.44)mm、(3.01±0.55)mm,明显低于对照组的(2.10±0.44)分、(1.83±0.45)分、(2.70±0.70)mm、(3.70±0.84)mm(P<0.05)。试验组治疗后螺旋体计数(2.47±0.65)个、杆菌计数(72.08±4.40)个少于对照组的(6.31±0.87)、(76.35±5.05)个,球菌计数(125.32±14.20)个多于对照组的(116.46±20.21)个(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。试验组治疗后物质生活状态、心理功能、躯体功能、社会功能评分分别为(85.10±5.42)、(83.28±9.46)、(82.10±10.06)、(84.15±10.14)分,明显高于对照组的(75.20±6.56)、(75.64±9.34)、(74.78±11.10)、(75.28±11.23)分(P<0.05)。结论对妊娠期牙周炎患者予以西帕依固龈液联合牙周治疗效果良好,安全性较高,可使龈沟液炎性因子、牙周指标、微生物指标、生活质量得到改善,值得推广。

Objective To evaluate the efficacy of Xipayi mouth rinse combined with periodontal therapy on gestational periodontitis.Methods 70 patients with gestational periodontitis were divided into a control group and an experimental group by drawing lots,each with 35 patients.The control group received routine periodontal therapy,and the experimental group received Xipayi mouth rinse and periodontal therapy.Both groups were compared in terms of clinical efficacy,inflammatory factors[visfatin(VF),prostaglandin E2(PGE2),monocyte chemoattractant protein(MCP-1),interleukin-6(IL-6)]in gingival crevicular fluid,periodontal indicators[periodontal probing depth(PD),sulcus bleeding index(SBI),plaque index(PLI),attachment loss(AL)],microbial indicators,adverse reactions,and quality of life.Results The total clinical effective rate of the experimental group was 97.14%,which was significantly higher than 77.14%of the control group(P<0.05).After treatment,the levels of VF,PGE2,MVP-1 and IL-6 in the experimental groups were(31.40±7.55)μg/L,(48.80±6.52)ng/L,(81.38±8.18)ng/L and(3.58±0.61)ng/L,which were significantly lower than(40.59±6.52)μg/L,(56.48±9.05)ng/L,(91.06±10.10)ng/L and(4.36±0.68)ng/L in the control group(P<0.05).After treatment,SBI,PLI,AL and PD in the experimental groups were(1.17±0.38)points,(1.11±0.32)points,(2.06±0.44)mm and(3.01±0.55)mm,which were significantly lower than(2.10±0.44),(1.83±0.45),(2.70±0.70)mm and(3.70±0.84)mm in the control group(P<0.05).After treatment,the count of spirochetes and bacilli were(2.47±0.65)and(72.08±4.40)in the experimental group,which were less than(6.31±0.87)and(76.35±5.05)in the control group;the count of cocci of(125.32±14.20)in the experimental group was more than(116.46±20.21)in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the scores of material life status,psychological function,physical function and social function of the experimental group were(85.10±5.42),(83.28±9.46),(82.10±10.06)and(84.15±10.14)points,which were significantly higher than(75.20±6.56),(75.64±9.34),(74.78±11.10)and(75.28±11.23)points of the control group(P<0.05).Conclusion The combined treatment of Xipayi mouth rinse and periodontal therapy for patients with gestational periodontitis has a good effect and high safety,and can improve inflammatory factors in gingival crevicular fluid,periodontal indicators,microbial indicators,and quality of life.It is worth promoting.