自研经颅贴片超声探头的临床初步应用效果

Research on the clinical application effect of transcranial ultrasound patch probe

目的评价自研经颅贴片超声探头的性能及其在临床应用中的稳定性和安全性。方法本研究为横断面研究,选取2023年10-12月在空军军医大学唐都医院进行健康体检的50例受检者,通过简单随机方法均分为两组。两组受检者分别使用自研经颅贴片超声探头和普通经颅多普勒超声(TCD)探头,在蹲位、坐位和直立三种状态下进行TCD检查。同一受检者由两位经验丰富的超声医师(A、B)分别使用不同探头(自研经颅贴片超声探头/普通TCD探头)各完成一次试验。比较自研经颅贴片超声探头和普通TCD探头在不同姿势(蹲位、坐位、直立)下测得的大脑中动脉(MCA)血流超声参数的差异。同时,评估操作人员对两种探头的使用满意度,包括获取满意图像所需时间、操作舒适度及易操作性等方面。考察受检者在检查过程中的舒适感受,并对两种探头的信号采集稳定性进行综合评价。结果应用自研经颅贴片超声探头与普通TCD探头检测MCA在不同姿势下各项超声参数比较差异无统计学意义(均P>0.05)。评估医师对使用两种探头的总体满意度,Kappa值为0.582比0.600。受检者在使用自研经颅贴片超声探头与普通TCD探头检查过程中均未发生受检不适/意外事件。两种探头信号采集均良好且稳定。结论采用自研经颅贴片超声探头能够较好完成经颅多普勒超声检查,该研究为移动状态下脑血流实时监测和评估提供了新思路。

Objective To evaluate the performance of the self-developed transcranial ultrasound patch probe as well as its stability and safety in clinical applications.Methods This study was a cross-sectional study.Fifty healthy subjects in Tangdu Hospital from October to December 2023 were randomly and equally divided into two groups using a simple randomization method.The transcranial Doppler ultrasound(TCD)examinations were performed using the self-developed transcranial ultrasound patch probe and normal TCD probe alternatively in each group from squatting to sitting and then to standing posture.Two experienced sonographers(A,B)each completed one test for the same subject using the above two different probes.The differences of the ultrasound parameters of middle cerebral artery(MCA)blood flow measured by the self-developed transcranial ultrasound patch probe and the normal TCD probe in different postures(squatting,sitting,standing)were compared.At the same time,operator satisfaction with the use of the two probes was assessed in terms of time taken to obtain satisfactory images,operational comfort,and ease of handling.In addition,the subject's comfort during the examination was examined,and the signal acquisition stability of the two probes was comprehensively evaluated.Results There was no significant difference in detection of various ultrasound parameters of MCA between using the transcranial patch probe and the normal TCD probe(all P>0.05).The overall satisfaction of transcranial ultrasound patch probe and normal TCD probe was quite similar.The transcranial ultrasound patch probe acquired favorable and stable signals.No subjects experienced adverse events/accidents during the examination of the subjects using the transcranial ultrasound patch probe as well as the normal TCD probe.Both probes had good and stable signal acquisition.Conclusions TCD examinations could be well performed using the transcranial ultrasound patch probe,which might provide a potential new method for real-time monitoring and evaluating of cerebral blood flow of a moving subject.