肺部磨玻璃结节的过度诊断与过度治疗现状及对策

Current situation and countermeasure of overdiagnosis and overtreatment of pulmonary ground-glass nodule

肺癌是世界上发病率和死亡率最高的恶性疾病之一,因此早期发现、早期诊断、早期治疗是降低肺癌死亡率的重要手段。低剂量计算机体层摄影(LDCT)筛查可以显著降低高危人群肺癌的死亡率,但是随着LDCT筛查项目的广泛开展,越来越多的无症状肺部磨玻璃结节被发现,过高的检出率可能导致过度诊断、过度治疗、浪费医疗资源及增加受检者焦虑心理。

Lung cancer has emerged as one of the most prevalent malignant diseases globally,characterized by the highest incidence and mortality rates.Thus,early detection,diagnosis,and treatment play crucial roles in reducing the mortality associated with lung cancer.Research has revealed that low-dose computed tomography(LDCT)screening significantly reduces the mortality rate of lung cancer among high-risk populations.Nevertheless,the expansion of LDCT screening initiatives has led to an increased detection of asymptomatic pulmonary ground-glass nodule(GGN).This heightened detection rate may result in overdiagnosis,overtreatment,inappropriate utilization of medical resources,and heightened anxiety amongst patients.