单细胞视角下的肿瘤浸润免疫细胞

Tumor-infiltrating immune cells from a single-cell perspective

免疫微环境与肿瘤的治疗和预后密切相关。肿瘤浸润免疫细胞在肿瘤不同阶段中异质性显著。单细胞RNA测序(scRNA-seq)在单细胞水平解析细胞的生物学行为、机制及其与机体的关系,已广泛应用于各种肿瘤微环境的研究。研究显示,应用scRNA-seq技术能深入剖析肿瘤浸润免疫细胞的免疫特征。

Immune microenvironment is closely related to the treatment and prognosis of tumors.Tumor-infiltrating immune cells exhibit significant heterogeneity in different stages of tumors.Single-cell RNA sequencing(scRNA-seq)is widely used in the study of various tumor microenvironment to analyze the biological behavior,mechanisms,and relationship between cells and the body at the single-cell level.The results showed that using scRNA-seq can deeply understand the immune characteristics of tumor-infiltrating immune cells.