温州市乳腺癌死亡及减寿分析

Death and life loss due to breast cancer in Wenzhou City

目的分析2014—2022年浙江省温州市女性乳腺癌死亡变化趋势及寿命损失情况,为乳腺癌防治提供依据。方法通过温州市慢性病监测管理信息系统收集2014—2022年温州市户籍女性乳腺癌死亡病例资料,计算粗死亡率;采用2010年第六次全国人口普查数据计算中国人口标化率(中标率),采用Segi's世界标准人口构成计算世界人口标化率(世标率);采用潜在减寿年数(PYLL)、潜在减寿率(PYLLR)和平均减寿年数(AYLL)分析寿命损失情况;采用平均年度变化百分比(AAPC)分析死亡率、PYLLR和AYLL变化趋势。结果2014—2022年温州市女性乳腺癌累计死亡2523例,居女性恶性肿瘤死亡顺位第五位。女性乳腺癌粗死亡率为7.13/10万,呈上升趋势(AAPC=2.186%,P<0.05);中标率为5.93/10万,世标率为4.39/10万,无明显变化趋势(AAPC=-0.617%、-0.602%,均P>0.05)。女性乳腺癌粗死亡率随年龄增长呈上升趋势(P<0.05);2014—2022年≥65岁组女性乳腺癌粗死亡率呈上升趋势(AAPC=3.283%,P<0.05),15~<45岁、45~<65岁组无明显变化趋势(AAPC=-1.011%、-1.850%,均P>0.05)。女性乳腺癌PYLL为41227.50人年,PYLLR为1.23‰,AYLL为19.44年/人;其中AYLL呈下降趋势(AAPC=-1.969%,P<0.05),PYLLR无明显变化趋势(AAPC=-0.527%,P>0.05)。结论2014—2022年温州市女性乳腺癌粗死亡率呈上升趋势,AYLL呈下降趋势,≥65岁女性是重点防制人群。

Objective To investigate the mortality and life loss of female breast cancer in Wenzhou City,Zhejiang Province from 2014 to 2022,so as to provide the evidence for prevention and control of breast cancer.Methods Data of female breast cancer deaths in Wenzhou City were collected through the Wenzhou Chronic Disease Monitoring and Management information System from 2014 to 2012.The mortality of breast cancer was calculated,and standardized by the data from the Sixth Chinese National Population Census in 2010(Chinese-standardized rate)and the world standard population first introduced by Segi(world-standardized rate).The life loss were measured using potential years of life lost(PYLL),rate of potential years of life lost(PYLLR)and average years of life lost(AYLL).The trends in mortality,PYLLR and AYLL were analyzed using the average annual percent change(AAPC).Results Totally 2523 deaths were reported due to breast cancer from 2014 to 2022,ranking fifth in the order of female malignant tumor deaths.The crude mortality of female breast cancer was 7.13/105,showing an increasing trend with AAPC of 2.186%(P<0.05).The Chinese population-standardized mortality and global population-standardized mortality were 5.93/105 and 4.39/105,showing no significant trend with AAPC of-0.617%and-0.602%(both P>0.05),respectively.The crude mortality of female breast cancer appeared a tendency towards a rise with age(P<0.05).The crude mortality of breast cancer in females aged 65 years and older showed an increasing trend(AAPC=3.283%,P<0.05),but there were no significant tendency aged 15 to<45 years and 45 to<65 years(AAPC=-1.011%and-1.850%,both P>0.05).The PYLL,PYLLR and AYLL of breast cancer were 41227.50 person-years,1.23‰and 19.44 years per person,respectively.AYLL showed a decreasing trend(AAPC=-1.969%,P<0.05),and PYLLR showed no significant trend(AAPC=-0.527%,P>0.05).Conclusions The mortality of female breast cancer in Wenzhou City appeared a tendency towards a rise from 2014 to 2022,and AYLL appeared a downward trend.Females aged 65 years and older were the key groups for the prevention and control of breast cancer.