摘要
钒因其可塑性、可锻性良好而广泛应用于钢铁制造、航空航天和医疗等行业,但大量钒化合物被排放到环境中,人类主要通过环境和职业暴露于钒。钒及其化合物可导致生殖系统、呼吸系统、神经系统和免疫系统等多系统损伤,其毒性作用机制可能与氧化应激、表观遗传损伤、DNA损伤、细胞凋亡及细胞增殖失调有关。本文对钒暴露导致的健康危害及其作用机制进行综述,为钒及其化合物的毒性作用研究提供参考。
Vanadium is widely used in the steel manufacturing,aerospace and medical industries because of its good plasticity and malleability,and is released into the environment in large quantities.Human were exposed mainly through environmental and occupational exposure.Vanadium and its compounds can cause multi-system damage to the reproductive,respiratory,neurological,and immune systems,and the toxic mechanisms may be related to oxidative stress,epigenetic damage,DNA damage and repair,apoptosis,and dysregulation of cell proliferation.This article summarizes the health hazards caused by vanadium exposure and its mechanism,providing the reference for the studies into the toxic effects of vanadium and its compounds.
作者
李佳萍
蒋兆强(综述)
李涛(审校)
LI Jiaping;JIANG Zhaoqiang;LI Tao(School of Public Health,Hangzhou Medical College,Hangzhou,Zhejiang 310013,China)
出处
《预防医学》
2024年第9期772-775,780,共5页
China Preventive Medicine Journal
基金
浙江省基础公益研究计划项目(LTGY23H260008)
浙江省医药卫生科技计划项目(2023KY654)
浙江省一流学科(A类)公共卫生与预防医学。
关键词
钒
毒性作用
氧化应激
DNA损伤
机制
vanadium
toxic effect
oxidative stress
DNA damage
mechanism
