摘要
目的考察疏肝清脂方加减对2型糖尿病合并脂代谢异常患者的临床疗效。方法160例患者随机分为对照组和观察组,每组80例,对照组给予常规治疗,观察组在对照组基础上加用疏肝清脂方加减,疗程8周。检测临床疗效、脂代谢指标(TC、TG、LDL-C、HDL-C、Chemerin、ApoA1、ApoB、LPa)、糖代谢指标(FBG、2 hPG、HbA1c)、鸢尾素、摄食抑制因子-1、中医证候评分、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组HDL-C、鸢尾素升高(P<0.05),TC、TG、LDL-C、Chemerin、ApoA1、ApoB、LPa、糖代谢指标、摄食抑制因子-1、中医证候评分降低(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论疏肝清脂方加减可安全有效地调节2型糖尿病合并脂代谢异常患者糖脂代谢及鸢尾素、摄食抑制因子-1、Chemerin水平。
AIM To investigate the clinical effects of Modified Shugan Qingzhi Decoction on patients with type 2 diabetes mellitus complicated with dyslipidemia.METHODS One hundred and sixty patients were randomly assigned into control group(80 cases)for 8-week intervention of conventional treatment,and observation group(80 cases)for 8-week intervention of both Shugan Qingzhi Decoction and conventional treatment.The changes in clinical effects,lipid metabolism indices(TC,TG,LDL-C,HDL-C,Chemerin,ApoA1,ApoB,LPa),glucose metabolism indices(FBG,2 hPG,HbA1c),irisin,food ingestion inhibitor-1,TCM syndrome scores and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed increased HDL-C,irisin(P<0.05),and decreased TC,TG,LDL-C,Chemerin,ApoA1,ApoB,LPa,glucose metabolism indices,food ingestion inhibitor-1,TCM syndrome scores(P<0.05),especially for the observation group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with type 2 diabetes mellitus complicated with dyslipidemia,Modified Shugan Qingzhi Decoction can safely and effectively regulate glucose and lipid metabolism and levels of irisin,feeding inhibition factor-1,Chemerin.
作者
钟钻仪
张慧芬
阳婉容
ZHONG Zuan-yi;ZHANG Hui-fen;YANG Wan-rong(Department of Endocrinology,Dongguan Municipal Hospital of Traditional Chinese Medicine,Dongguan 523000,China)
出处
《中成药》
CAS
CSCD
北大核心
2024年第9期2954-2958,共5页
Chinese Traditional Patent Medicine
基金
广东省中医药局科研项目(20213020)。
关键词
疏肝清脂方
常规治疗
2型糖尿病
脂代谢异常
Shugan Qingzhi Decoction
conventional treatment
type 2 diabetes mellitus
dyslipidemia