MXenes用于近红外二区肿瘤光热诊疗的研究进展

Research progress of MXenes for second near-infrared window photothermal diagnosis and therpay of tumors

由近红外二区(NIR-Ⅱ,1000~1350 nm)光触发光热剂进行光热治疗是一种新兴的肿瘤治疗方式,具有良好的应用前景。过渡金属碳化物、氮化物或碳氮化合物(MXenes)具有超薄层状结构、独特的电子性质、比表面积大、光热转换效率高、良好的亲水性及易于表面功能化等优点,可作为一类具有优良性质的光热剂应用于NIR-Ⅱ区肿瘤光热治疗。本文介绍了NIR-Ⅱ区光热治疗的优势,概括了MXenes的光热性能和MXenes胶体溶液稳定性,重点总结了MXenes在NIR-Ⅱ区肿瘤光热诊疗的研究进展,并阐述了该领域未来发展所面临的挑战和机遇。

Photothermal tumor therapy with second near-infrared(NIR-II,1000-1350 nm)phototriggered photothermal agents is a promising emerging method of tumor therapy.Transition metal carbides,nitrides,and carbonitridges compounds(MXenes)have advantages such as ultra-thin layered structure,unique electronic properties,large specific surface area,high photothermal conversion efficiency,good hydrophilicity,and easy surface functionalization,making them suitable as photothermal agents for tumor photothermal therapy.This review introduces the advantages of NIR-II photothermal therapy,summarizes the photothermal performance of MXenes and the stability of MXenes colloidal solution.At the same time,the research progress of MXenes in NIR-II tumor photothermal therapy was discussed,and the challenges and opportunities faced in the future development of this field were elaborated.