中医药调节肠道治疗帕金森病作用机制研究进展

Research progress of traditional Chinese medicine regulating intestinal flora in the treatment of Parkinson's disease

帕金森病(PD)是中枢神经系统第二大退行性疾病,发病率逐年上升,其发病机制复杂,至今尚未完全阐明。有研究认为,肠道菌群紊乱所导致的代谢紊乱和炎症反应可以通过微生物-肠-脑轴,传导到大脑,可能会导致PD的发病。现在已有大量临床研究表明使用中医药调节肠道对治疗PD具有多种优势,可以有效改善PD患者的症状,且无明显不良反应。笔者通过检索国内外相关文献,探索肠道影响PD发病的作用机制及中医药对肠道菌群的作用,对中医药从肠道论治PD的最新进展予以综述,以期为PD的相关研究及中医药治疗提供参考。

Parkinson's disease(PD)is the second most degenerative disease of the central nervous system,and its incidence is increasing year by year.Some studies believe that metabolic disorders and inflammatory responses caused by intestinal flora disorders can be transmitted to the brain through the microbial-gut-brain axis,which may lead to the onset of PD.At present,a large number of clinical studies have shown that the use of traditional Chinese medicine to regulate intestinal flora has multiple advantages in the treatment of PD,and can effectively improve the symptoms of PD patients without obvious side effects.By searching a large number of relevant literatures at home and abroad,the author explored the mechanism of intestinal flora affecting the pathogenesis of PD and the effect of traditional Chinese medicine on intestinal flora,and reviewed the latest progress of traditional Chinese medicine treating PD from the gut,with a view to providing references for PD related research and traditional Chinese medicine treatment of PD.