泻痢康胶囊介导肠道菌群调控TNFR1/RIP1/ComplexⅠ信号通路治疗HIV/AIDS腹泻的机制探析

Mechanism analysis of Xielikang Capsule mediated intestinal flora regulating TNFR1/RIP1/Complex I signaling pathway in treatment of HIV/AIDS diarrhea

艾滋病腹泻是艾滋病患者常见的临床并发症,其病程长、缠绵难愈,严重影响了此类患者的工作与生活。艾滋病腹泻的发生与异常分泌的TNF-α激活RIP1/ComplexⅠ通路、肠黏膜屏障受损,菌群结构失衡相关。泻痢康胶囊能调节TNF-α分泌,修复肠黏膜屏障,调节菌群结构,减少CD_(4)^(+)T淋巴细胞的持续耗损,促进免疫机能修复。文章浅析泻痢康胶囊治疗艾滋病腹泻的作用机制,以期丰富其科学内涵。

Diarrhea in AIDS is a prevalent clinical complication among AIDS patients.It has a protracted course,is persistent and refractory to treatment,seriously influencing the work and life of these patients.The occurrence of diarrhea in AIDS is associated with the abnormal secretion of TNF-αactivating the RIP1/Complex I pathway,the damaged intestinal mucosal barrier,and the imbalance of flora structure.Xielikang Capsule can regulate the secretion of TNF-α,repair the intestinal mucosal barrier,regulate the flora structure,reduce the continuous depletion of CD_(4)^(+)T lymphocytes,and promote the restoration of immune function.This article explores the mechanism of Xielikang Capsule in treating diarrhea in AIDS to further enrich its scientific connotation,with the anticipation of facilitating the research.