宣肺止咳颗粒联合布地奈德对咳嗽变异性哮喘患儿肺功能的影响

Effect of Xuanfei Zhike Granules combined with budesonide on lung function of children with cough-variant asthma

目的观察宣肺止咳颗粒联合布地奈德对咳嗽变异性哮喘(CVA)患儿肺功能的影响。方法将我院90例CVA患儿随机分为对照组与治疗组各45例。对照组给予布地奈德治疗,治疗组给予宣肺止咳颗粒联合布地奈德治疗。比较两组患儿疗效、症状、日间咳嗽、夜间咳嗽评分、肺功能、过敏反应指标,对患儿进行为期1年随访疾病复发率。结果治疗后,治疗组总有效率明显高于对照组(P<0.05);两组症状、日间咳嗽、夜间咳嗽评分、免疫球蛋白E(IgE)、嗜酸性粒细胞(EOS)均明显低于治疗前,治疗组上述指标均明显低于对照组(P<0.05);两组第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值(FEV1%)、呼气峰流速(PEF)均明显高于治疗前,治疗组上述指标均明显高于对照组(P<0.05);治疗组1年随访疾病复发率低于对照组(P<0.05)。结论宣肺止咳颗粒联合布地奈德治疗CVA患儿,可有效提高疗效,改善咳嗽等症状,提高肺功能,降低IgE、EOS水平和疾病复发率,促进康复。

Objective To observe the effect of Xuanfei Zhike Granules combined with budesonide on lung function of children with cough-variant asthma(CVA).Methods A total of 90 children with CVA were randomly divided into control group and treatment group with 45 cases each.Control group was treated with budesonide,and treatment group was treated with Xuanfei Zhike Granules on the basis of control group.The efficacy,symptoms,daytime cough and nighttime cough scores,pulmonary function and allergic reaction indexes were compared between the two groups,and the disease recurrence rate was followed up for 1 year.Results After treatment,the total effective rate of treatment group was significantly higher than that of control group(P<0.05);the symptoms,daytime cough,nighttime cough scores,immunoglobulin E(IgE)and eosinophils(EOS)in both groups were significantly lower than those before treatment,and were significantly lower in treatment group than those in control group(P<0.05);the forced expiratory volume(FEV1),forced expiratory volume at the first second(FEV1%),and peak expiratory flow rate(PEF)at the first day in both groups were significantly higher than those before treatment,and were significantly higher in treatment group than those in control group(P<0.05);the disease recurrence rate at 1-year follow-up in treatment group was significantly lower than that in control group(P<0.05).Conclusion Xuanfei Zhike Granules combined with budesonide can effectively improve the efficacy,improve cough and other symptoms,improve lung function,reduce IgE and EOS levels and disease recurrence rate,and promote recovery in treatment of CVA.