当归四逆汤联合氯化锶注射液治疗转移性骨肿瘤临床疗效观察

Efficacy of Danggui Sini Decoction combined with strontium chloride injection in treatment of metastatic bone tumors

目的观察当归四逆汤联合氯化锶注射液治疗转移性骨肿瘤临床疗效。方法将我院100例转移性骨肿瘤患者随机分为对照组与治疗组各50例。对照组采用氯化锶注射液治疗治疗组采用当归四逆汤联合氯化锶注射液治疗。比较两组骨痛、生存质量、转移性病灶疗效体质量指数(BMI)、Karnofsky功能状态评分(KPS)和骨痛评分,白蛋白(ALB)、自然杀伤(NK)细胞活性、CD4^(+)/CD8^(+)、缓激肽(BK)、β-内啡肽(β-EP)、碱性磷酸酶(ALP)、骨钙素(BGP)水平。结果治疗后,治疗组骨痛总有效率高于对照组(P<0.05);治疗组生存质量总有效率高于对照组(P<0.05);两组转移性病灶总缓解率差异无统计学意义(P>0.05);两组BMI高于治疗前,KPS和骨痛评分低于治疗前,治疗组BMI高于对照组,KPS和骨痛评分低于对照组(P<0.05)治疗组ALB、NK细胞活性、CD4^(+)/CD8^(+)高于治疗前并高于对照组(P<0.05)对照组ALB、NK细胞活性、CD4^(+)/CD8^(+)治疗前后差异无统计学意义(P>0.05);两组BK、β-EP、ALP、BGP水平低于治疗前治疗组BK、β-EP、ALP、BGP水平低于对照组(P<0.05)。结论当归四逆汤联合氯化锶注射液治疗转移性骨肿瘤,显著降低骨痛,提高生存质量,改善营养代谢和免疫功能,降低疼痛介质和骨代谢指标水平,但对转移性病灶的缩小作用不显著。

Objective To observe the efficacy of Danggui Sini Decoction combined with strontium chloride injection in treatment of metastatic bone tumors.Methods A total of 100 cases of metastatic bone tumors were randomly divided into control group and treatment group,with 50 cases each.Control group was treated with strontium chloride injection,and treatment group was treated with Danggui Sini Decoction on the basis of contrtol group.The efficacy of bone pain,quality of life,metastatic lesions,body mass index(BMI),Karnofsky functional status score(KPS)and bone pain score,albumin(ALB),natural killer(NK)cell activity,CD4^(+)/CD8^(+),bradykinin(BK),β-endorphins(β-EP),alkaline phosphatase(ALP)and osteocalcin(BGP)levels were compared between the two groups.Results After treatment,the total effective rate of bone pain in treatment group was higher than that in control group(P<0.05);the total effective rate of quality of life in treatment group was higher than that in control group(P<0.05);there was no statistically significant difference in the total response rate between the two groups of metastatic lesions(P>0.05);both groups had higher BMI than before treatment,while KPS and bone pain scores were lower than before treatment;the BMI of treatment group was higher than that of control group,and the KPS and bone pain scores were lower than those of control group(P<0.05);the ALB and NK cell activity,CD4^(+)/CD8^(+)in treatment group were higher than those before treatment and in control group(P<0.05),but there was no statistically significant difference in ALB and NK cell activity,CD4^(+)/CD8^(+)before and after treatment in control group(P>0.05);the levels of two sets of BK,β-EP,ALP,and BGP were lower than before treatment,and were lower in treatment group than those of control group(P<0.05).Conclusion Danggui Sini Decoction combined with strontium chloride injection can significantly reduce bone pain,improve quality of life,improve nutrient metabolism and immune function,and reduce the level of pain mediators and bone metabolism indexes in treatment of metastatic bone tumors,but has no significant effect on the shrinkage of metastatic lesions.