心力衰竭心肌纤维化治疗进展

Research progress in myocardial fibrosis in heart failure

心力衰竭是多种心血管疾病的终末阶段,心肌纤维化是心力衰竭发生发展的重要病理生理机制,针对心力衰竭心肌纤维化的治疗在不断发展,本文将介绍醛固酮受体拮抗剂、钠-葡萄糖共转运蛋白2抑制剂、血管紧张素受体脑啡肽酶抑制剂、可溶性鸟苷酸环化酶刺激剂、袢利尿剂、吡非尼酮及microRNA-132的新型反义疗法在心肌纤维化治疗中的进展,以期为临床实践中心肌纤维化的治疗提供思路。

Heart failure(HF)is the final stage of a variety of cardiovascular diseases.Myocardial fibrosis is an important pathophysiological mechanism in the occurrence and development of HF.The treatment of myocardial fibrosis for HF is constantly developing.This article will introduce the progress in the treatment of myocardial fibrosis,such as aldosterone receptor antagonists,sodium-glucose co-transporter 2 inhibitors,angiotensin receptor neprilysin inhibitors,soluble guanylate cyclase stimulators,loop diuretics,pirfenidone and microRNA-132 antisense therapy,in order to provide some insights into the treatment of myocardial fibrosis in clinical practice.