首发未服药精神分裂症患者临床症状与炎症因子的相关分析

Analysis of the correlation between clinical symptoms and inflammatory factors in first-episode unmedicated schizophrenia

目的分析首发未服药精神分裂症患者临床症状与炎症因子之间的关系。方法招募了76名参与者,分为首发未服药精神分裂症患者组及健康对照组。对所有被试进行血清炎症因子水平检测,同时收集患者社会人口学资料,阳性和阴性症状量表得分(PANSS),简明精神病评定量表(BPRS)得分。比较两组之间炎症因子水平差异,分析有差异的炎症因子与临床症状之间的相关性,采用ROC曲线分析炎症因子水平对精神分裂症的诊断价值。结果与健康对照组相比,研究组中的白细胞介素(IL)-1β,IL-4,IL-8,IL-13,碱性成纤维细胞生长因子(bFGF),γ干扰素诱导蛋白-10(IP-10)和单核细胞趋化因子-1(MCP-1)的水平显著升高(P<0.05),血管内皮生长因子(VEGF)-D的水平低于健康对照(P<0.05)。同时发现IL-1β,MCP-1,IL-13与PANSS量表,BPRS量表及其分量表均有一定的相关性(均P<0.05)。最后通过ROC曲线分析发现bFGF(AUC=0.9944)是诊断效能较好的血清炎症因子。结论血清炎症因子与精神分裂症关系密切,同时对首发未服药精神分裂症的诊断有较高价值。

Objective To investigate and analyze the relationship between clinical symptoms and inflammatory factors in first-episode unmedicated schizophrenia.Methods Seventy-six participants were recruited and divided into a group of patients with first-episode unmedicated schizophrenia and a healthy control group.Serum inflammatory factor levels were tested for all subjects,and patient sociodemographic data,Positive and Negative Symptom Scale scores(PANSS),and Brief Psychiatric Rating Scale scores(BPRS)scale scores were also collected.We compared the differences in inflammatory factor levels between the two groups,analyzed the correlation between the different inflammatory factors and clinical symptoms,and used ROC curves to analyze the diagnostic value of inflammatory factor levels for schizophrenia.Results The levels of IL-1β,IL-4,bFGF,IL-13,IL-8,IP-10,and MCP-1 were significantly higher(P<0.05),and the levels of VEGF-D were lower(P<0.05)in the study group compared to healthy controls.It was also found that IL-1β,MCP-1,and IL-13 were correlated with PANSS scale,BPRS scale,and their subscales(all P<0.05).Finally,bFGF(AUC=0.9944)was found to be a serum inflammatory factor with better diagnostic efficacy by ROC curve analysis.Conclusion Serum inflammatory factor is closely related to schizophrenia and is also of high value in the diagnosis of first-episode unmedicated schizophrenia.