无抽搐电休克对重性抑郁患者的疗效及对血清BDNF,炎性因子水平的影响

Efficacy of Non Convulsive Electroconvulsive Therapy for Severe Depression and Its Impact on Serum Levels of BDNF and Inflammatory Factors

目的探讨无抽搐电休克疗法(modified electroconvulsive therapy,MECT)治疗重症抑郁疗效及对血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF),炎性因子水平的影响。方法本研究选择2021年2月~2023年1月84例重症抑郁患者,数字表法随机分为两组,对照组42例患者采用帕罗西汀治疗,观察组42例在对照组基础上联合MECT治疗。比较两组治疗前后汉密尔顿焦虑,抑郁量表(HAMA,HAMD)以及血清BDNF,白细胞介素1β(interleukin-1β,IL-1β),IL-10水平。结果治疗后两组患者HAMA评分,HAMD评分均显著降低,且治疗后观察组两项评分均显著低于对照组(P<0.05);治疗后两组患者血清BDNF,IL-10水平显著升高,IL-1β水平均显著降低,且治疗后观察组各项指标变化优于对照组(P<0.05)。结论MECT治疗重症抑郁能够降低焦虑,抑郁情绪,并提升血清BDNF水平,调节炎性因子水平。

Objective To explore the efficacy of modified electroconvulsive therapy(MECT)in the treatment of severe depression and its influence on the levels of serum Brain-derived neurotrophic factor(BDNF)and inflammatory factors.Methods 84 patients with severe depression from February 2021 to January 2023,and they were randomly divided them into two groups using a numerical table method.42 patients in the control group were treated with Paroxetine,and 42 patients in the observation group were treated with MECT on the basis of the control group.The Hamilton Anxiety,Depression Scale(HAMA,HAMD),as well as serum BDNF and interleukin-1 levels,Interleukin-1 and IL-10 level between two groups before and after treatment were compared.Results After treatment,the HAMA score and HAMD score of both groups of patients were significantly reduced,and the observation group had significantly lower scores than the control group(P<0.05).After treatment,the serum levels of BDNF and IL-10 in both groups of patients significantly increased,the IL-βlevels were significantly reduced,and the changes in various indicators in the observation group were better than those in the control group after treatment(P<0.05).Conclusion MECT treatment for severe depression can reduce anxiety and depressive emotions,increase serum BDNF levels,and regulate inflammatory factor levels.