艾司西酞普兰联合无抽搐电休克治疗对糖尿病合并抑郁患者的效果

The application value of escitalopram combined with electroconvulsive shock therapy in diabetic patients with depression

目的研究艾司西酞普兰联合无抽搐电休克治疗在糖尿病合并抑郁患者中的应用价值及对患者负性情绪,心理的影响。方法选择从2021年6月~2022年6月在我院接受治疗的130例糖尿病合并抑郁患者作为观察对象。按随机数表法将患者分成观察组及对照组,每组各65例。两组均常规予以胰岛素,阿卡波糖及二甲双胍等降糖药物治疗,对照组在此基础上另给予艾司西酞普兰,观察组则在对照组的用药基础上另实施无抽搐电休克疗法,两组均治疗2个月,而后对比两组疗效,治疗前及治疗2个月后的汉密尔顿焦虑/抑郁量表(HAMA/HAMD)评分,焦虑/抑郁自评量表(SAS/SDS)评分,以及两组不良反应。结果观察组的总有效率是98.46%(64/65),较对照组的86.15%(56/65)明显更高,差异有统计学意义(P<0.05)。治疗后两组的HAMA,HAMD评分以及SAS及SDS评分均分别较治疗前更低,且观察组较对照组也明显更低,差异有统计学意义(P<0.05)。观察组不良反应的总发生率是9.23%(6/65),与对照组的6.15%(4/65)比较,差异无统计学意义(P>0.05)。结论艾司西酞普兰联合无抽搐电休克对糖尿病合并抑郁患者的应用价值较好,能够更好的改善患者的负性情绪,且安全性较高。

Objective To study the application value of escitalopram combined with electroconvulsive shock treatment in diabetic patients with depression and its influence on negative mood and psychology.Methods A total of 130 patients with diabetes and depression treated in our hospital from June 2021 to June 2022 were selected for observation.Patients were divided into observation group and control group by random number table method,with 65 patients in each group.Both groups were routinely treated with hypoglycemic drugs such as insulin,acarbose and metformin,the control group was given escitalopram on this basis,the observation group on the basis of the control group were treated for 2 months with electroconvulsive shock treatment,and then the two groups of Hamilton's anxiety/depression scale(HAMA/HAMD)score before and 2 months after treatment,self-rating of anxiety/depression(SAS/SDS)score,and the two groups of adverse effects were compared.Results The overall response rate of the observation group was 98.46%(64/65),which was significantly higher than 86.15%(56/65)of the control group,and the difference was statistically significant(P<0.05).The HAMA,HAMD scores,SAS and SDS scores were lower than before treatment,and the observation group was significantly lower than the control group respectively,the difference was statistically significant(P<0.05).The overall incidence of adverse effects in the observation group was 9.23%(6/65),compared with 6.15%(4/65)in the control group,had not significant(P>0.05).Conclusion Escitalopram and electroconvulsive shock have good application value in patients with diabetes and depression,and can be better to regulate the negative mood,with high safety.