培元涤痰开郁方联合经颅直流电刺激对卒中后抑郁患者的影响

The Effect of Peiyuan Ditan Kaiyu Formula Combined with Transcranial Direct Current Stimulation in Post-stroke Depression Patients

目的探讨培元涤痰开郁方联合经颅直流电刺激(tDCS)对卒中后抑郁患者的效果及对其结合珠蛋白(Hp),微小RNA-30a-5p(miR-30a-5p)的影响。方法选取丹东市中医院收治的96例卒中后抑郁患者作为研究对象,随机将其分为对照组和观察组各48例。对照组给予经颅直流电刺激治疗,观察组在此基础上增加培元涤痰开郁方治疗,比较两组疗效。结果观察组临床总有效率(93.75%vs79.19%)高于对照组(P<0.05)。与对照组比较,观察组治疗后美国国立卫生研究院卒中量表(NIHSS)评分,汉密尔顿抑郁量表(HAMD-17)评分降低更明显(P<0.05)。与对照组比较,观察组治疗后Hp,miR-30a-5p相对表达量降低更明显(P<0.05)。结论培元涤痰开郁方联合tDCS可提高卒中后抑郁患者临床疗效,降低血清Hp水平及miR-30a-5p相对表达量,改善机体炎症水平。

Objective To explore the effect of Peiyuan Ditan Kaiyu Recipe combined with transcranial direct current stimulation(tDCS)on binding globin(Hp)and microRNA-30a-5p(miR-30a-5p)in patients with poststroke depression.Methods 96 patients with post-stroke depression admitted to Dandong Traditional Chinese Medicine Hospital were selected as the research subjects and randomly divided into a control group and an observation group with 48 cases each.The control group was treated with transcranial direct current stimulation,while the observation group was treated with Peiyuan Ditan Kaiyu Formula.The therapeutic effects were compared between the two groups.Results The total clinical effective rate of the observation group(93.75%vs 79.19%)was higher than that of the control group(P<0.05).Compared with the control group,the observation group showed a more significant decrease in the National Institutes of Health Stroke Scale(NIHSS)and Hamilton Depression Scale(HAMD-17)scores after treatment(P<0.05).Compared with the control group,the relative expression levels of Hp and miR-30a-5p in the observation group decreased more significantly after treatment(P<0.05).Conclusion The combination of Peiyuan Ditan Kaiyu Formula and tDCS can improve the clinical efficacy of post-stroke depression patients,reduce serum Hp levels and the relative expression of miR-30a-5p,and improve the level of inflammation in the body.