m^(6)A甲基化在肺癌发生发展中调控机制的研究进展

Research progress on the regulatory mechanisms of m^(6)A methylation in the occurrence and development of lung cancer

N6-甲基腺嘌呤修饰(N^(6)-methyladenosine,m^(6)A)是真核细胞中最常见的RNA修饰形式之一,属于表观遗传学修饰的范畴,涉及多种肿瘤的发生和发展。肺癌是全球癌症死亡率最高的恶性肿瘤之一,其发病机制复杂,且早期诊断困难,治疗手段有限。m^(6)A修饰在肺癌中发挥重要作用,相关分子的表达异常导致m^(6)A修饰的失调,从而影响到肺癌的发展。这一现象提示m^(6)A修饰相关分子可能成为肺癌治疗的潜在靶点或诊断标志物。因此,本文综述了m^(6A)修饰在肺癌发生发展过程中的作用,探讨了其与肺癌细胞生物行为及微环境的关系,并讨论了m^(6)A修饰与肺癌相关信号通路之间的相互作用,为深入理解m^(6)A甲基化在肺癌发生和发展中的作用提供了宝贵的参考,对于开发新的诊断和治疗策略具有重要意义。

N6⁃methyladenosine(m^(6)A)is one of the most prevalent forms of RNA modification in eukaryotic cells,falling un⁃der the category of epigenetic modifications,and it plays a crucial role in the onset and development of various types of tumors.Lung cancer stands as one of the malignant tumors with the highest mortality rate globally,characterized by a complex pathogene⁃sis,difficulty in early diagnosis,and limited therapeutic options.m^(6)A modifications play a significant role in lung cancer,with ab⁃normalities in the expression of related factors leading to dysregulation of m^(6)A modifications,subsequently impacting the progres⁃sion of lung cancer.This phenomenon suggests that m^(6)A modification⁃related factors may serve as potential targets for lung cancer therapy or as diagnostic biomarkers.Hence,this article provides a comprehensive review of the role of m^(6)A modifications in the de⁃velopment and progression of lung cancer,exploring their relationship with the biological behaviors of lung cancer cells and the tu⁃mor microenvironment,and discussing the interactions between m^(6)A modifications and lung cancer⁃related signaling pathways.This review offers valuable insights for a deeper understanding of the role of m^(6)A methylation in the onset and development of lung cancer,holding significant implications for the development of novel diagnostic and therapeutic strategies.