瑞芬太尼诱发痛觉过敏机制及防治策略的研究新进展

Recent progress in research on mechanisms and preventive strategies for remifentanil-induced hyperalgesia

瑞芬太尼具有起效快、半衰期短、长时间输注无蓄积等优点,是临床工作中广泛应用的阿片类药物。瑞芬太尼除了在术中发挥镇痛作用,还可导致术后机体对疼痛敏感性增高,即瑞芬太尼诱发痛觉过敏(remifentanil-induced hyperalgesia, RIH),严重影响病人术后恢复及生活质量。RIH的发生发展机制错综复杂,涉及受体功能失调、离子通道改变以及神经炎症等诸多因素。本文就RIH发生机制及防治策略的研究进展进行综述,旨在为今后分子机制研究及临床诊疗策略提供理论参考。

Remifentanil is an opioid medicine,which widely used in clinical practice due to its rapid onset,short half-life,and lack of accumulation with prolonged infusion.Apart from its analgesic effect during surgery,remifentanil can also increase postoperative pain sensitivity,which is known as remifentanil-induced hyperalgesia(RIH).RIH has an significant affect on patients'postoperative recovery and quality of life.The mechanisms of the development of RIH are complex and intricate.This article reviews recent progress in the understanding of the mechanisms and preventive strategies for RIH,aiming to provide theoretical references for future molecular mechanism research and clinical treatment strategies.