m6A甲基化修饰在前列腺癌中的研究进展

Advances in m6A methylation modification in prostate cancer

N6甲基腺苷修饰(m6A)甲基化修饰是一种常见的表观遗传学修饰,可改变RNA的结构和功能,影响RNA的翻译与结构的稳定性,在基因的表达调控、恶性肿瘤的发生及发展中起重要作用,已成为肿瘤领域的研究热点。该文从m6A甲基化修饰的分子调节机制及生物效应出发,重点叙述了甲基转移酶复合体、去甲基化酶、甲基化阅读器这3类m6A调节因子在前列腺癌中的研究进展。越来越多的m6A调节因子被发现其异常表达与前列腺癌的发生、发展密切相关,有助于临床从分子层面进一步了解前列腺癌的发生、发展机制。但如何将这些m6A调节因子应用于前列腺癌的诊疗还有待做进一步的研究和探索。

N6 methyladenosine modification(m6A)methylation modification is a common epigenetic modification,which can change the structure and function of RNA,affect the translation and structural stability of RNA,play an important role in gene expression regulation,the occurrence and development of malignant tumors,and it has become a research focus in the field of cancer.Based on the molecular regulation mechanism and biological effects of m6A methylation modification,this artical focuses on the research progress of three types of m6A regulatory factors,including methyltransferase complex,demethylase and methylation reader in prostate cancer.More and more m6A regulatory factors have been found to be closely related to the occurrence and development of prostate cancer,which is helpful to further understand the occurrence and development mechanism of prostate cancer from the molecular level.However,how to apply these m6A regulators to the diagnosis and treatment of prostate cancer needs to be further studied and explored.