大麻二酚抗癫痫的作用机制

The mechanism of cannabidiol in anti-epilepsy

大麻二酚是大麻中主要的非精神活性成分,具有广泛的治疗作用,特别是作为附加药物在治疗难治性癫痫患者中取得了肯定的疗效,目前已显示出良好的抗癫痫药物前景。该文综述了目前有关大麻二酚抗癫痫作用机制信号通路的研究进展。前期,学者们主要报道其与大麻素受体、G蛋白偶联受体55、甘氨酸受体、腺苷受体、瞬时受体电位香草酸通道1、5-羟色胺受体、γ-氨基丁酸受体、电压门控离子通道等作用靶点相关,在后续研究中发现过氧化物酶体增殖物激活受体γ、P-糖蛋白、磷脂酰肌醇3-激酶γ在大麻二酚的抗癫痫机制中也起到一定作用。以后需不断探索其机制,明确靶点间的联系,寻找新的干预靶点,研究其治疗潜力并为开发更安全的药物提供参考。

Cannabidiol is the main non-psychoactive component of cannabis,which has a wide range of therapeutic effects,especially as an additional drug in the treatment of refractory epilepsy patients has achieved a positive effect and has shown good prospects for antiepileptic drugs.This article reviews the current research progress on the signaling pathways of the anti-epileptic mechanism of cannabidiol.Early,scholars mainly reports with the cannabinoid receptors,55 G protein coupled receptors,glycine,adenosine receptors,transient receptor,potential vanilloid receptor channel 1,serotonin receptors,gamma aminobutyric acid receptor,voltage-gated ion channels and other related targets.Subsequent studies have found that peroxisome proliferator-activated receptorγ,P-glycoprotein and phosphatidylinositol 3-kinaseγalso play a role in the anti-epileptic mechanism of cannabidiol.In the future,it is necessary to continuously explore its mechanism,clarify the relationship between targets,find new intervention targets,study its therapeutic potential and provide reference for the development of safer drugs.