苯磺酸瑞马唑仑对肝切除术患者苏醒质量及血清炎症因子水平的影响

Effects of Remazolam Besylate on Recovery Quality and Serum Inflammatory Factors in Patients Undergoing Hepatectomy

目的观察苯磺酸瑞马唑仑应用于肝切除术患者对苏醒质量及血清炎症因子水平的影响。方法将2022年1月至2023年11月赣南医学院第一附属医院收治的需行肝切除术患者70例纳入本研究,采用随机数字表法将患者分为两组各35例。对照组给予丙泊酚麻醉诱导及维持,观察组给予苯磺酸瑞马唑仑。比较两组术中不同时刻平均动脉压(MAP)、心率(HR)水平,苏醒质量相关指标及不良反应发生率,比较两组患者麻醉前、手术结束时、术后24 h炎症因子水平。结果两组不同时刻MAP及HR水平比较差异均无统计学意义(均P>0.05)。相较于对照组,观察组呼吸恢复时间、睁眼时间、气管导管拔除时间、恢复室停留时间均更短,且手术结束时、术后24 h白细胞介素(IL)-1β、IL-6及肿瘤坏死因子(TNF-α)水平,以及不良反应发生率均低于对照组(均P<0.05)。结论苯磺酸瑞马唑仑应用于肝切除术患者可改善苏醒质量,且降低血清炎症因子水平,不良反应低。

Objective To observe the effects of remazolam besylate on the quality of recovery and serum inflammatory factors levels in patients undergoing hepatectomy.Methods Seventy patients requiring hepatectomy admitted to the First Affiliated Hospital of Gannan Medical College from January 2022 to November 2023 were included in this study,and the patients were divided into two groups of 35 cases each using the random number table method.Propofol anaesthesia was given for induction and maintenance in the control group,and remazolam benzenesulfonate was given in the observation group.Compared the levels of mean arterial pressure(MAP)and heart rate(HR)at different moments during the operation,the indicators related to the quality of awakening and the incidence of adverse reactions,and we compared the levels of inflammatory factors before anaesthesia,at the end of the operation,and at 24 hours after the operation in the two groups.Results There was no statistically significant difference in the comparison of MAP and HR levels between the two groups at different moments(all P>0.05).Compared with the control group,the observation group had shorter respiratory recovery time,eye-opening time,tracheal tube removal time,and recovery room stay time,and the levels of interleukin(IL)-1β,IL-6,and tumour necrosis factor(TNF-α)at the end of the operation and at 24 hours post-surgery,as well as the incidence of adverse reactions,were lower than those of the control group(all P<0.05).Conclusions Remazolam benzoate can improve the quality of recovery and reduce the level of serum inflammatory factors with low side effects in patients undergoing hepatectomy.