PCT、CRP、WBC在全身炎性反应综合征诊疗中的临床意义

The Clinical Significance of PCT,CRP,and WBC in the Diagnosis and Treatment of Systemic Inflammatory Response Syndrome

目的探讨降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)在全身炎性反应综合征诊疗中的临床意义。方法选取2020年7月至2023年7月漳浦县医院70例全身炎性反应综合征患者、100例健康体检者,分别设为观察组、对照组。检测两组受检者的降钙素原、C反应蛋白、白细胞计数,对比两组检测结果。将全身炎性反应综合征患者根据其是否为感染性疾病分为感染组(39例)与非感染组(31例),对比感染组与非感染组的炎性因子指标,对比三项炎性因子指标在单一检测与联合检测时对于感染性全身炎性反应综合征的诊断结果。根据全身炎性反应综合征患者的预后情况将其分成病死组(8例)与存活组(62例),对比病死组与存活组的炎性因子指标。结果观察组的降钙素原、C反应蛋白、白细胞计数均比对照组更高(P<0.05)。在全身炎性反应综合征患者中,感染组的降钙素原、C反应蛋白、白细胞计数均高于非感染组(P<0.05)。在诊断感染性全身炎性反应综合征时,降钙素原、C反应蛋白、白细胞计数联合检测的灵敏度、特异度、准确率、阳性预测值、阴性预测值均比各项指标单一检测高(P<0.05)。28 d病死组患者的降钙素原、C反应蛋白、白细胞计数均高于28 d存活组(P<0.05)。结论降钙素原、C反应蛋白、白细胞计数作为炎性因子指标在全身炎性反应综合征患者中普遍出现异常增高情况,联合检测三项炎性因子指标可辅助判断感染性全身炎性反应综合征,具有良好的诊断价值,且三项指标对于全身炎性反应综合征的预后预测可起到一定的参考作用。

Objective To explore the clinical significance of procalcitonin(PCT),C-reactive protein(CRP),and white blood cell count(WBC)in the diagnosis and treatment of systemic inflammatory response syndrome.Methods From July 2020 to July 2023,70 patients with systemic inflammatory response syndrome and 100 healthy individuals underwent physical examinations in Zhangpu County Hospital were selected as the study group and control group,respectively.The levels of procalcitonin,C-reactive protein and white blood cell count in two groups of subjects were detected,and the results of the two groups were compared.The patients with systemic inflammatory response syndrome were divided into infection group and non infection group according to whether they were infectious diseases.The inflammatory factor indicators of infection group and non infection group were compared,and the diagnosis results of infectious systemic inflammatory response syndrome for three inflammatory factor indicators in single detection and joint detection were compared.According to the prognosis of patients with systemic inflammatory response syndrome,they were divided into death group and survival group,and the inflammatory factor indicators of the death group and survival group were compared.Results The study group had higher levels of procalcitonin,C-reactive protein and white blood cell count than the control group(P<0.05).In patients with systemic inflammatory response syndrome,the infection group had higher levels of procalcitonin,C-reactive protein,and white blood cell count than the non infection group(P<0.05).When diagnosing infectious systemic inflammatory response syndrome,the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of the combined detection of procalcitonin,C-reactive protein,and white blood cell count are higher than those of single detection of various indicators(P<0.05).In patients with systemic inflammatory response syndrome,the 28 day death group had higher levels of procalcitonin,C-reactive protein,and white blood cell count than the 28 day survival group(P<0.05).Conclusions Procalcitonin,C-reactive protein,and white blood cell count are commonly abnormally elevated as inflammatory factor indicators in patients with systemic inflammatory response syndrome.The combined detection of these three inflammatory factor indicators can assist in the diagnosis of infectious systemic inflammatory response syndrome and has good diagnostic value.Moreover,these three indicators can play a certain reference role in predicting the prognosis of systemic inflammatory response syndrome.