胸腺法新联合纤支镜吸痰灌洗治疗重症肺炎伴急性呼吸衰竭患者的效果

Effects of Thymalfasin combined with fiberoptic bronchoscopy sputum suction lavage in treatment of patients with severe pneumonia complicated with acute respiratory failure

目的:观察胸腺法新联合纤支镜吸痰灌洗治疗重症肺炎(SP)伴急性呼吸衰竭(ARF)患者的效果。方法:选取2021年11月至2023年11月该院收治的80例SP伴ARF患者进行前瞻性研究,按照随机数字表法将其分为对照组与研究组各40例。对照组给予纤支镜吸痰灌洗治疗,研究组在对照组基础上联合胸腺法新治疗。比较两组临床疗效,治疗前后血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))]、肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC]、炎性因子[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-8(IL-8)]水平,以及不良反应发生率。结果:研究组治疗总有效率为90.00%(36/40),高于对照组72.50%(29/40),差异有统计学意义(P<0.05);治疗后,两组Pa O_(2)、Sa O_(2)水平均高于治疗前,且研究组高于对照组,两组Pa CO_(2)水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组FVC、FEV1、FEV1/FVC水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组CRP、PCT、IL-8水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胸腺法新联合纤支镜吸痰灌洗治疗SP伴ARF患者可提高治疗总有效率和肺功能指标水平,改善血气分析指标水平,降低炎性因子水平,其效果优于单纯纤支镜吸痰灌洗治疗。

Objective:To observe effects of Thymalfasin combined with fiberoptic bronchoscopy sputum suction lavage in treatment of patients with severe pneumonia(SP)complicated with acute respiratory failure(ARF).Methods:A prospective study was conducted on 80 patients with SP and ARF admitted to this hospital from November 2021 to November 2023.According to the random number table method,they were divided into control group and study group,with 40 cases in each group.The control group was treated with fiberoptic bronchoscopy sputum suction lavage,while the study group was treated with Thymalfasin on the basis of that of the control group.The clinical efficacy,the levels of blood gas analysis indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),arterial oxygen saturation(SaO_(2))],the lung function indexes[forced vital capacity(FVC),forced expiratory volume in the one second(FEV1),FEV1/FVC],and the inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),interleukin-8(IL-8)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 90.00%(36/40),which was higher than that of the control group 72.50%(29/40),and the difference was statistically significant(P<0.05).After the treatment,the levels of PaO_(2)and SaO_(2)in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the PaCO_(2)levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of FVC,FEV1 and FEV1/FVC in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of CRP,PCT and IL-8 in the two groups were lower than those before the treatment,those in the study group were lower than the control group,those in the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Thymalfasin combined with fiberoptic bronchoscopy sputum suction and lavage in the treatment of the SP patients with ARF can improve the total effective rate of treatment and the levels of lung function indexes,improve the levels of blood gas analysis indexes,and reduce the levels of inflammatory factors.Moreover,it is superior to simple fiberoptic bronchoscopy sputum suction lavage treatment.