布地奈德联合阿奇霉素序贯治疗肺炎支原体肺炎患儿的效果

Effects of Budesonide combined with Azithromycin sequential therapy in children with mycoplasma pneumonia

目的:观察布地奈德联合阿奇霉素序贯治疗肺炎支原体肺炎患儿的效果。方法:选取2021年8月至2023年8月该院收治的70例肺炎支原体肺炎患儿进行前瞻性研究,按照随机数字表法分为研究组与对照组各35例。对照组给予阿奇霉素序贯治疗,研究组在对照组的基础上联合布地奈德雾化吸入治疗,比较两组临床疗效、炎性指标[血清C反应蛋白(CRP)、白细胞计数(WBC)]水平、血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、血氧饱和度]水平和不良反应发生率。结果:研究组治疗总有效率为97.14%,明显高于对照组的74.29%,差异有统计学意义(P<0.05);治疗后,两组CRP、WBC等炎性指标水平低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);治疗后,两组血氧饱和度、PaO_(2)水平高于治疗前,且研究组高于对照组,两组PaCO_(2)水平低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:布地奈德联合阿奇霉素序贯治疗肺炎支原体肺炎患儿可提高治疗总有效率,改善血气分析指标水平,以及降低炎性指标水平,效果优于单纯阿奇霉素序贯治疗。

Objective:To observe effects of Budesonide combined with Azithromycin sequential therapy in children with mycoplasma pneumonia.Methods:A prospective study was conducted on 70 children with mycoplasma pneumonia admitted to this hospital from August 2021 to August 2023.According to the random number table method,they were divided into study group and control group,35 cases in each group.The control group was treated with Azithromycin sequential therapy,while the study group was treated with Budesonide aerosol inhalation on the basis of that of the control group.The clinical efficacy,the inflammatory indexes[serum C-reactive protein(CRP),white blood cell count(WBC)]levels,the blood gas analysis indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),blood oxygen saturation]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 97.14%,which was significantly higher than 74.29%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CRP,WBC and other inflammatory indexes in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of blood oxygen saturation and PaO_(2)in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the PaCO_(2)level of the two groups was lower than that before the treatment,and that of the study group was lower than that of the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Budesonide combined with Azithromycin sequential therapy for the children with mycoplasma pneumonia can improve the total effective rate of treatment,improve the levels of blood gas indexes,and reduce the levels of inflammatory indexes.Moreover,it is superior to simple Azithromycin sequential therapy.