自体血清联合玻璃酸钠滴眼液治疗白内障术后干眼症患者的效果

Effects of autologous serum combined with Sodium hyaluronate eye drops in treatment of patients with dry eye after cataract surgery

目的:观察自体血清联合玻璃酸钠滴眼液治疗白内障术后干眼症患者的效果。方法:回顾性分析2022年3月至2023年3月该院收治的82例白内障术后干眼症患者的临床资料,根据治疗方案不同将其分为对照组和观察组各41例。对照组采用玻璃酸钠滴眼液治疗,观察组在对照组基础上联合自体血清治疗,比较两组治疗前后泪膜功能指标[非接触式泪膜破裂时间(NIBUT)、非侵入式泪河高度(NITMH)]水平、炎性因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]水平、生命质量[视功能相关生命质量量表(NEI-VFQ-25)]评分和临床症状改善评分。结果:治疗后,观察组NIBUT和NITMH水平均高于对照组,差异有统计学意义(P<0.05);治疗后,观察组TNF-α和IL-1β水平均低于对照组,差异有统计学意义(P<0.05);治疗后,两组NEI-VFQ-25评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,观察组眼表疾病指数量表(OSDI)、眼红、睑板腺评分均低于对照组,差异有统计学意义(P<0.05)。结论:自体血清联合玻璃酸钠滴眼液治疗白内障术后干眼症患者可提高泪膜功能指标水平和NEI-VFQ-25评分,降低炎性因子水平和临床症状改善评分,效果优于单纯玻璃酸钠滴眼液治疗。

Objective:To observe effects of autologous serum combined with Sodium hyaluronate eye drops in treatment of dry eye patients after cataract surgery.Methods:The clinical data of 82 patients with dry eye after cataract surgery admitted to this hospital from March 2022 to March 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and observation group,41 cases in each group.The control group was treated with Sodium hyaluronate eye drops,while the observation group was treated with autologous serum on the basis of that of the control group.The tear film function indexes[non-contact tear film breakup time(NIBUT),non-invasive tear meniscus height(NITMH)]levels,the inflammatory factors[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]levels,the quality of life[national eye institute visual function questionnaire(NEI-VFQ-25)]score,and the clinical symptom improvement score were compared between the two groups before and after the treatment.Results:After the treatment,the levels of NIBUT and NITMH of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-αand IL-1βin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the NEI-VFQ-25 scores of the two groups were higher than those before the treatment,that in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the scores of ocular surface disease index(OSDI),eyelid redness and meibomian gland in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Autologous serum combined with Sodium hyaluronate eye drops can improve the levels of tear film function indexes,the NEI-VFQ-25 scores,and reduce the levels of inflammatory factors and the clinical symptom improvement scores in the patients with dry eye after cataract surgery.Moreover,it is superior to simple Sodium hyaluronate eye drops.