宝鸡地区鼻咽癌患者HPV感染状态与预后探究

Study on HPV infection status and prognosis of patients with nasopharyngeal carcinoma in Baoji area

目的探讨宝鸡地区鼻咽癌患者人乳头瘤病毒(HPV)感染情况,分析HPV感染与鼻咽癌预后的关系。方法收集2011年7月至2022年12月宝鸡市中心医院收治的经病理检查确诊为鼻咽癌的59例患者作为研究对象。使用p16蛋白Envision法检测HPV感染情况;分析鼻咽癌标本中p16蛋白阳性表达情况;比较p16蛋白阳性与阴性患者的临床特征及生存情况。结果59例鼻咽癌标本中,30例p16蛋白表达阳性,阳性率为50.8%。p16蛋白阳性、阴性鼻咽癌患者的性别、年龄、吸烟与饮酒情况、T分期、N分期及病理学分型比较,差异无统计学意义(P>0.05)。p16蛋白阳性与阴性患者的3年总体生存率(OS)分别为86.0%和68.7%,5年OS分别为81.2%和58.9%,p16蛋白阳性患者的OS略高于阴性患者,但差异无统计学意义(P>0.05);p16蛋白阳性与阴性患者的3年无病生存率(DFS)分别是81.5%和55.1%,p16蛋白阳性患者的DFS高于阴性患者(P<0.05)。结论宝鸡地区HPV感染率较低,HPV阳性患者的生存期长于HPV阴性患者。

Objective To investigate the infection of human papillomavirus(HPV)in patients with nasopharyngeal carcinoma in Baoji area,and to analyze the relationship between HPV infection and prognosis of nasopharyngeal carcinoma.Methods A total of 59 patients with nasopharyngeal carcinoma diagnosed by pathological examination in Baoji Central Hospital from July 2011 to December 2022 were collected as the research objects.HPV infection was detected by p16 protein Envision method;the positive expression of p16 protein in nasopharyngeal carcinoma specimens was analyzed;the clinical characteristics and survival of patients with positive and negative p16 protein were compared.Results In 59 cases of nasopharyngeal carcinoma specimens,30 cases of p16 protein expression was positive,the positive rate was 50.8%.There were no significant differences in gender,age,smoking and drinking,T stage,N stage and pathological type between p16 protein positive and negative patients with nasopharyngeal carcinoma(P>0.05).The 3-year overall survival(OS)of p16 protein positive and negative patients were 86.0%and 68.7%,respectively,and the 5-year OS were 81.2%and 58.9%,respectively,the OS of p16 protein positive patients was slightly higher than that of negative patients,but the difference was not statistically significant(P>0.05);the 3-year disease free survival(DFS)of p16 protein positive and negative patients were 81.5%and 55.1%,respectively,the DFS of p16 protein positive patients was higher than that of negative patients(P<0.05).Conclusion The infection rate of HPV in Baoji area is low,and the survival time of HPV positive patients is longer than that of HPV negative patients.