铁死亡在急性肾损伤进展为慢性肾脏病中的作用

Ferroptosis in the progression from acute kidney injury to chronic kidney disease

急性肾损伤(AKI)是临床常见的急危重症,发病率高、死亡率高。近年来研究表明,AKI后的肾脏适应不良性修复可导致慢性肾脏病(CKD)。铁死亡是一种新型的非凋亡形式的细胞死亡方式,其特征是铁过载和脂质过氧化,在AKI向CKD的进展中发挥重要作用。本文就铁死亡的经典调控机制及其在AKI进展为CKD中参与的病理机制作一综述。

Acute kidney injury(AKI)is an acute and critical illness with high morbidity and mortality.In recent years,a growing body of studies have shown that renal maladaptation following AKI results in chronic kidney disease(CKD).Ferroptosis,a novel form of non-apoptotic cell death characterized by iron overload and lipid peroxidation,is believed to play a significant role in the progression of AKI to CKD.This article provides a review of the classical regulatory mechanisms of ferroptosis and its potential involvement in the pathological mechanisms in the progression of AKI to CKD.