肥胖促进慢性肾脏病发生发展的机制和防治对策

Mechanisms and interventions in the development of chronic kidney disease promoted by obesity

肥胖等代谢疾病和慢性肾脏病(CKD)是威胁人类健康的重要慢性疾病,在我国呈现快速增长态势。典型的肥胖相关肾病有其特殊的组织形态学特征和临床表现,然而其他CKD也可合并肥胖。本文主要介绍肥胖促进CKD发生和发展的可能机制,以及传统和创新的治疗方法。

Metabolic diseases such as obesity and chronic kidney disease will be an important chronic disease threatening human health,showing a rapid growth in China.Typical obesity-related glomerulopathy has its special histomorphologic features and clinical manifestations,however,there are also other chronic glomerular and tubulointerstitial kidney disease coexist with obesity.This article focuses on the epidemiologic features of obesity in CKD,possible pathogenic mechanisms,and traditional and innovative therapeutic approaches.