内皮素受体拮抗剂治疗肾脏疾病的研究进展

Advances on endothelin receptor antagonists in the treatment of kidney diseases

内皮素与肾脏疾病密切相关,激活内皮素受体A后促进血管收缩,引起肾脏炎症、纤维化和细胞增殖,导致肾损伤,通过拮抗内皮素受体可以保护肾功能。目前越来越多的研究证实,内皮素受体拮抗剂能减少多种肾脏疾病的尿蛋白,保护肾功能,本文就内皮素拮抗剂治疗肾脏疾病的进展作一简述。

Endothelin is closely associated with kidney diseases.Activation of endothelin receptor A promotes vasoconstriction,inflammation,fibrosis,and cell proliferation,leading to kidney damage.By antagonizing the endothelin receptors,renal function can be protected.Currently,endothelin receptor antagonists are primarily used to treat pulmonary arterial hypertension.However,numerous clinical trials have confirmed that endothelin receptor antagonists are significantly effective in reducing proteinuria and protecting renal function.They are promising as a new type of medication for the treatment of various kidney diseases.