某院153例苯二氮[艹卓]类药物过量患者血药浓度检测结果分析

Analysis of Blood Drug Concentration Test Results of 153 Patients with Benzodiazepine Overdose in a Hospital

目的:对云南省某医院2019—2021年既往临床诊断为苯二氮[艹卓]类药物过量的患者进行血药浓度检测结果分析。方法:回顾性分析2019—2021年既往临床诊断为苯二氮[艹卓]类药物过量的患者血药浓度检测结果,从性别差异、年龄分布、不同药物检出情况等方面进行分析和探讨。结果:64岁以上老年患者是检出艾司唑仑过量的主要群体,占比高达76.5%;艾司唑仑过量近三年呈现逐年递减的趋势(P<0.05);18岁以下青少年是检出氯硝西泮过量的主要群体;临床诊断为苯二氮[艹卓]类药物过量的女性患者多于男性患者;氯硝西泮过量的男童多于女童;检出阿普唑仑过量的女性患者多于男性患者。结论:64岁以下人群是临床诊断为苯二氮[艹卓]类药物过量及中毒的主要群体,女性患者多于男性患者。检出艾司唑仑过量的患者中,64岁以上老年患者所占比例最高,18岁以下人群是检出氯硝西泮过量的主要群体,男童多于女童。

Objective:To analyze the blood concentration test results of patients with previous clinical diagnosis of benzodiazepine overdose in a hospital in Yunnan Province from 2019 to 2021.Methods:The blood concentration detection results of patients diagnosed with benzodiazepine overdose from 2019 to 2021 were retrospectively analyzed and discussed from the aspects of gender difference,age distribution,different drug detection and so on.Results:The elderly patients over 64 years old were the main group of esazolam overdose,accounting for 76.5%.The excess of esazolam showed a decreasing trend year by year in recent three years(P<0.05).Adolescents under 18 years old were the main group of clonazepam overdose.More women than men were clinically diagnosed with benzodiazepine overdose.More boys had clonazepam overdose than girls.Alprazolam overdose was detected in more women than men.Conclusion:People under 64 years old are the main group of patients diagnosed with benzodiazepine overdose and poisoning,and there are more female patients than male patients.Among the patients with estazolam overdose,the elderly patients over 64 years old accounted for the highest proportion,and the group under 18 years old was the main group with clonazepam overdose,with more boys than girls.