阿托伐他汀钙片联合阿司匹林治疗脑血栓的效果

Effect of Atorvastatin Calcium Tablets Combined with Aspirin in the Treatment of Cerebral Thrombosis

目的:探讨阿托伐他汀钙片与阿司匹林联合治疗脑血栓的效果。方法:回顾性分析2020年1月—2022年4月我院接受诊治的73例脑血栓患者作为研究对象。根据治疗方案的不同将患者分为试验组(n=39)和对照组(n=34)。对照组单用阿司匹林,试验组在对照组的基础上加用阿托伐他汀钙片,比较两组的治疗效果。结果:试验组临床有效率高于对照组(P<0.05);试验组治疗后颈动脉斑块面积、内膜中层厚度、血小板聚集率及NIHSS评分均低于对照组(P<0.05);试验组治疗后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均低于对照组,高密度脂蛋白胆固醇(HDL-C)高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿托伐他汀钙片联合阿司匹林治疗脑血栓效果确切且安全性良好,优于单用阿司匹林。

Objective:To investigate the effect of atorvastatin calcium tablets combined with aspirin in the treatment of cerebral thrombosis.Methods:A retrospective analysis of 73 patients with cerebral thrombosis who were treated in our hospital from January 2020 to April 2022 was conducted.Patients were divided into experimental group(n=39)and control group(n=34)according to different treatment regimens.The control group was treated with aspirin alone,and the experimental group was treated with atorvastatin calcium tablets on the basis of the control group.The therapeutic effects of the two groups were compared.Results:The clinical effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,the carotid plaque area,intima-media thickness,platelet aggregation rate and NIHSS score in the experimental group were lower than those in the control group(P<0.05).After treatment,total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in the experimental group were lower than those in the control group,and high density lipoprotein cholesterol(HDL-C)was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Atorvastatin calcium tablets combined with aspirin is effective and safe in the treatment of cerebral thrombosis,which is better than aspirin alone.