优甲乐与甲状腺片分别治疗妊娠期甲状腺功能减退症的效果比较

Comparison of the Effects of Euthyrox and Thyroid Tablets in the Treatment of Hypothyroidism During Pregnancy

目的:探讨优甲乐治疗对妊娠期甲状腺功能减退症患者甲状腺激素水平的影响。方法:选取2022年1月—2023年7月本院诊治的妊娠期甲减患者180例作为研究对象,根据随机数字表法分为优甲乐组90例与常规组90例。常规组给予甲状腺片治疗,优甲乐组给予优甲乐治疗,两组均连续用药至分娩,比较两组治疗总有效率、血清促甲状腺激素、游离甲状腺素含量、不良反应发生情况及不良妊娠结局情况。结果:优甲乐组治疗6个月后总有效率为98.89%,高于常规组的90.00%(P<0.05);优甲乐组治疗6个月血清促甲状腺激素、游离甲状腺素含量优于常规组(P<0.05);优甲乐组治疗6个月不良反应发生率为2.22%,低于常规组的11.11%(P<0.05);优甲乐组流产、胎膜早破、早产、剖宫产发生率低于常规组(P<0.05)。结论:优甲乐能提高妊娠期甲减患者的总体治疗效果,改善游离甲状腺素含量、促甲状腺激素含量,可降低不良妊娠结局发生率,还具有较高的应用安全性。

Objective:To investigate the effect of euthyrox treatment on thyroid hormone levels in patients with hypothyroidism during pregnancy.Methods:A total of 180 patients with hypothyroidism during pregnancy diagnosed and treated in our hospital from January 2022 to July 2023 were selected as the research objects.According to the random number table method,they were divided into 90 patients in the euthyrox group and 90 patients in the conventional group.The routine group was treated with thyroid tablets,and the euthyrox group was treated with euthyrox.Both groups were treated continuously until delivery.The total effective rate,serum thyroid stimulating hormone,free thyroxine content,adverse reactions and adverse pregnancy outcomes were compared between the two groups.Results:The total effective rate of the Euthyrox group after 6 months of treatment was 98.89%,which was higher than 90.00%of the conventional group(P<0.05).The levels of serum thyroid stimulating hormone and free thyroxine in the Euthyrox group were better than those in the conventional group after 6 months of treatment(P<0.05).The incidence of adverse reactions in the Euthyrox group after 6 months of treatment was 2.22%,which was lower than 11.11%in the conventional group(P<0.05).The incidence of abortion,premature rupture of membranes,premature delivery and cesarean section in the euthyrox group was lower than that in the conventional group(P<0.05).Conclusion:Euthyrox can improve the overall therapeutic effect of patients with hypothyroidism during pregnancy,improve the content of free thyroxine and thyroid stimulating hormone,reduce the incidence of adverse pregnancy outcomes,and has high application safety.