Bending short DNAs as transversely isotropic rings in series

将短DNA简化成串联的横观各向同性环进行弯曲

Despite the significance of the high flexibility exhibited by short DNAs,there remains an incomplete understanding of their anomalous persistence length.In this study,we propose to model each basic unit of gene sequences within short DNAs as a transversely isotropic ring.Our comprehensive model analysis successfully replicates the observed high flexibility of short DNAs and also displays the impact of sequence dependence,aligning with experimental findings.Furthermore,our analysis suggests that the bending behavior of short DNAs can be effectively described by the Timoshenko beam theory with the consideration of shear.

尽管短DNA表现出的高柔性具有重要意义,但对其异常持续长度的机理仍未完全弄清楚.在本研究中,我们建议将短DNA中基因序列的每个基本单元建模为一个横观各向同性环.我们的模型分析成功重演了所观测到的短DNA高柔性,并显示了序列依赖性的影响,与实验结果一致.此外,我们的分析表明,短DNA的弯曲行为可以通过考虑剪切的Timoshenko梁理论进行有效描述.