CT评估腹膜癌指数对老年卵巢癌术后复发转移的预测

Prognostic Value of CT Evaluation of Peritoneal Carcinoma Index in Postoperative Recurrence and Metastasis of Elderly Ovarian Cancer

目的探讨CT评估腹膜癌指数(CT-PCI)对老年卵巢癌术后复发转移的预测价值。方法选取2016年1月-2022年6月在扬州大学附属医院接受卵巢癌减灭术治疗的85例老年卵巢癌患者作为研究对象。随访至2023年12月(3例失访),经电子病历系统采集患者资料,Cox风险比例模型分析影响老年卵巢癌患者术后复发转移的因素。结果82例老年卵巢癌患者中出现复发转移者20例;复发转移组临床分期Ⅳ期、伴有淋巴结转移、腹膜转移、脉管浸润及分化程度为低分化和未分化者占比和CA125、CEA、Ki-67阳性率、CT-PCI评分均高于无复发转移组(P<0.05);Cox风险比例模型结果显示,临床分期Ⅳ期、腹膜转移、CA125、Ki-67阳性、CT-PCI评分均为影响老年卵巢癌患者术后复发转移的独立危险因素(P<0.05)。结论CT-PCI对老年卵巢癌术后复发转移具有一定的预测价值,可作为临床术后管理指导。

Objective To investigate the value of CT evaluation of peritoneal carcinoma index(CT-PCI)in predicting recurrence and metastasis of elderly ovarian cancer after operation.Methods A total of 85 elderly patients with ovarian cancer who received radical resection for ovarian cancer in the Affiliated Hospital of Yangzhou University from January 2016 to June 2022 were selected and followed up until December 2023(3 cases were lost).Patient data were collected through the electronic medical record system,Cox regression analysis was performed to analyze the factors affecting postoperative recurrence and metastasis of elderly patients with ovarian cancer.Results Recurrence and metastasis occurred in 20 of 82 elderly patients with ovarian cancer.The proportion of clinical stageⅣ,with lymph node metastasis,peritoneal metastasis,vascular invasion and poorly differentiated and undifferentiated,and CA125,CEA,Ki-67 positivity exrate,and CT-PCI scores in recurrent metastasis group were all higher than those in the group without recurrence and metastasis(P<0.05).Cox proportional hazards model showed that clinical stageⅣ,peritoneal metastasis,CA125,Ki-67 positivity rate,and CT-PCI scores were all independent risk factors affecting postoperative recurrence and metastasis in elderly patients with ovarian cancer(P<0.05).Conclusion CT-PCI has a certain predictive value for postoperative recurrence and metastasis of elderly ovarian cancer,It can be used as guidance for clinical postoperative management。