亲子关系与CL0CK基因rs1801260多态性对学前儿童亲社会行为的交互影响:性别的调节作用

The Interaction Effect of Parent-child Relationships and the CL0CK rs1801260 Polymorphism on Preschoolers'Prosocial Behaviors:The Moderating Role of Sex

研究探讨了亲子关系与CL0CK基因rs1801260多态性对学前儿童亲社会行为的交互影响及性别的调节作用。以694名学前儿童(M年龄=5.06岁,SD=0.87)及其父母为测试对象,收集儿童的睡液样本进行基因分型,由儿童父母填写亲子关系和儿童亲社会行为量表。研究结果发现,亲子亲密与亲子冲突对亲社会行为的主效应显著。亲子冲突、CL0CK基因rs1801260多态性和性别三重交互影响儿童的亲社会行为,即与携带C等位基因的男孩相比,携带TT基因型的男孩在低亲子冲突下会表现出更多的亲社会行为,在高亲子冲突下则表现出更少的亲社会行为。但亲子冲突与CL0CK基因rs1801260多态性对女孩亲社会行为的交互作用不显著。研究结果为深入理解学前儿童亲社会行为形成的基因一环境交互作用机制提供了证据。

The present study examined whether parent-child relationships interact with the CLOCK rs1801260 polymorphism to contribute to children's prosocial behaviors.The saliva of 694 preschoolers(Mage=5.06,SD=0.87)was extracted to genotype the CL0CK rs1801260 polymorphism,and children's parents were invited to complete questionnaires to assess parent-child relationships and children's prosocial behaviors.After controlling for age and family socioeconomic status,the results indicated that parent-child closeness was positively while parent-child conflict was negatively related to preschoolers'prosocial behaviors,and the significant interaction effect of parentchild conflict and the CLOCK rs1801260 polymorphism was found in boys but not girls.Compared with C allele carriers,boys with TT genotype developed more prosocial behaviors under the condition of lower parent-child conflict while fewer prosocial behaviors under the condition of higher parent-child conflict.The findings of the present study expand our knowledge about the G×E underpinnings of children's prosocial behaviors.